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Showing 1–17 of 17 results
Advanced filters: Author: Hermann E. Gaub Clear advanced filters

  • The adhesion of single DNA molecules on modified gold surfaces can be adjusted by surface potential, and the desorption forces of these interactions are measured by single-molecule force spectroscopy.

    • Matthias Erdmann
    • Ralf David
    • Hermann E. Gaub
    Research
    Nature Nanotechnology
    Volume: 5, P: 154-159

  • The assembly and evaluation of molecular structures on surfaces has been boosted by advances in single-molecule techniques. The development of such methods are continued here, showing that double-stranded DNA, bound to the tip of an atomic force microscope, can be deposited on the surface of a gold electrode using an electrical trigger.

    • Matthias Erdmann
    • Ralf David
    • Hermann E. Gaub
    Research
    Nature Chemistry
    Volume: 2, P: 745-749

  • The mechanical deposition of single molecules on a surface can be optically monitored with nanometre precision using a combination of total internal reflection fluorescence microscopy and atomic force microscopy.

    • Stefan K. Kufer
    • Mathias Strackharn
    • Hermann E. Gaub
    Research
    Nature Nanotechnology
    Volume: 4, P: 45-49

  • Mechanistic origins of force stability and bond kinetics of interaction of the receptor-binding domain from the SARS-CoV-2 spike protein with angiotensin-converting enzyme 2, a key selection factor for mutations, are revealed at the single-molecule resolution using magnetic tweezers and molecular dynamics simulations.

    • Magnus S. Bauer
    • Sophia Gruber
    • Jan Lipfert
    Research
    Nature Nanotechnology
    Volume: 19, P: 399-405

  • Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium.

    • Lukas F. Milles
    • Eduard M. Unterauer
    • Hermann E. Gaub
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Cellulosomes are cell surface enzyme complexes that digest lignocellulosic biomass. Here, Schoeler et al.characterize the strength of the ligand–receptor anchoring complex and find that it represents one of the strongest interactions known, and is strengthened under applied force by a catch bond mechanism.

    • Constantin Schoeler
    • Klara H. Malinowska
    • Michael A. Nash
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • A monovalent form of an engineered streptavidin can now be tethered to AFM cantilevers, representing a reliable anchoring tool with a well-defined pulling geometry for single-molecule force spectroscopy studies of proteins.

    • Fabian Baumann
    • Magnus S. Bauer
    • Diana A. Pippig
    Research
    Nature Nanotechnology
    Volume: 11, P: 89-94

  • Mechanobiology describes how biological systems respond to mechanical stimuli. This Review surveys basic principles, advantages and limitations of applying and combining atomic force microscopy-based modalities with complementary techniques to characterize the morphology, mechanical properties and functional response of complex biological systems to mechanical cues.

    • Michael Krieg
    • Gotthold Fläschner
    • Daniel J. Müller
    Reviews
    Nature Reviews Physics
    Volume: 1, P: 41-57

  • In recent years, single-molecule force spectroscopy techniques have been used to study how inter- and intramolecular interactions control the assembly and functional state of biomolecular machinery in vitro. Here we discuss the problems and challenges that need to be addressed to bring these technologies into living cells and to learn how cellular machinery is controlled in vivo.

    • Yves F Dufrêne
    • Evan Evans
    • Daniel J Müller
    Comments & Opinion
    Nature Methods
    Volume: 8, P: 123-127

  • A microfluidic chip is used to construct a microarray of proteins, each labeled with a dockerin tag, for high-throughput single-molecule force spectroscopy experiments using a single cohesin-modified cantilever.

    • Marcus Otten
    • Wolfgang Ott
    • Hermann E Gaub
    Research
    Nature Methods
    Volume: 11, P: 1127-1130

  • Atomic force microscopy (AFM)-based approaches enable the characterization and manipulation of biological and synthetic biointerfaces, including tissues, cells, membranes, proteins, nucleic acid and functional materials. In this Review, the advantages and limitations of imaging, sensing, parameterizing and designing biointerfaces using AFM techniques are discussed.

    • David Alsteens
    • Hermann E. Gaub
    • Daniel J. Müller
    Reviews
    Nature Reviews Materials
    Volume: 2, P: 1-16