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Nature Communications (2)

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Molecular biology

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Advanced filters: Author: Hessam Tabatabaee Clear advanced filters

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses p53 to support tumorigenicity.

Yu Chen Feng
Xiao Ying Liu
Lei Jin
ResearchOpen Access05 Oct 2020
Nature Communications

Volume: 11, P: 1-12
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.

Hamed Yari
Lei Jin
Xu Dong Zhang
ResearchOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-15

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c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

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