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Showing 1–2 of 2 results
Advanced filters: Author: Hidefumi Wakashin Clear advanced filters

  • Iwawura et al. identify a noncanonical role for NOD1, independent from its CARD-mediated proteoglycan sensing. Interactions between NOD1 and STAT5 are required for optimal lymphopoiesis in response to homeostatic cytokines.

    • Chiaki Iwamura
    • Hidetaka Ohnuki
    • Dragana Jankovic
    Research
    Nature Immunology
    Volume: 24, P: 2080-2090

  • Okamoto et al. report that APOL1 RNA, but not protein, expressed from chronic kidney disease (CKD)-associated alleles activates protein kinase R, inducing glomerular injury in a mouse model. The secondary structure of APOL1 risk variant RNA acts as a scaffold for protein kinase R, suggesting potential therapeutic strategies for CKD.

    • Koji Okamoto
    • Jason W. Rausch
    • Jeffrey B. Kopp
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-12