The transforming growth factor-β (TGFβ) signalling pathway is implicated in a variety of disorders, including cancer, fibrosis and inflammation, and has become an attractive target for drug development. Here, Akhurst and Hata present therapeutic strategies for intervening in this pathway and discuss agents currently under investigation while addressing the associated challenges in their development and application.
- Rosemary J. Akhurst
- Akiko Hata
