Nature Search

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

Mi-Hye Lee
Kangmo Lu
Shailendra B. Patel
Research01 Jan 2001
Nature Genetics

Volume: 27, P: 79-83
Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus

Brain-derived neurotrophic factor is produced in the brain and is a known regulator of energy homoeostasis. Here Urabe and colleagues show that brain-derived neurotrophic factor-producing haematopoietic cells control appetite by migrating into the hypothalamus, where they make contact with neurons.

Hiroshi Urabe
Hideto Kojima
Hiroshi Kimura
Research26 Feb 2013
Nature Communications

Volume: 4, P: 1-10
Tamoxifen triggers a transcriptional switch from proliferation to differentiation in the circumvallate taste epithelium in mice

Norihito Oura
Eriko Koyanagi-Matsumura
Hirohito Miura
ResearchOpen Access17 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

Hideto Kojima
Mineko Fujimiya
Lawrence Chan
Research21 Apr 2003
Nature Medicine

Volume: 9, P: 596-603
Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities

Mi-Hye Lee
Derek Gordon
Shailendra B Patel
Research21 Jun 2001
European Journal of Human Genetics

Volume: 9, P: 375-384
Complete remission of diabetes with a transient HDAC inhibitor and insulin in streptozotocin mice

A combination of HDAC inhibitors and transient insulin treatment corrects epigenetic alterations in bone marrow-derived hematopoietic cells of the pancreas and thymus, leading to diabetes remission in the STZ model.

Hideto Kojima
Miwako Katagi
Takahiko Nakagawa
ResearchOpen Access13 Jun 2023
Communications Biology

Volume: 6, P: 1-11
Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion

Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is memorized in the bone marrow and that it cannot be erased by conventional therapy.

Miwako Katagi
Tomoya Terashima
Hideto Kojima
ResearchOpen Access14 May 2021
Communications Biology

Volume: 4, P: 1-14
Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

Tph1 subset expresses IL21 to show B cell helper function, while Tph2 subset expresses high levels of cytotoxicity-related molecules and low IL21. Tph1 and Tph2 subsets exert distinct immunological functions in the clinical manifestations in SLE.

Noriyasu Seki
Hideto Tsujimoto
Tsutomu Takeuchi
ResearchOpen Access06 Mar 2024
Communications Biology

Volume: 7, P: 1-12
Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects

Yuuki Shirai
Junko Okano
Hideto Kojima
ResearchOpen Access29 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
Fructose might be a clue to the origin of preeclampsia insights from nature and evolution

Fructose might be a Clue to the Origin of Preeclampsia Insights from Nature and Evolution Preeclampsia is a hypertensive disorder of pregnancy. The pathogenesis remains unclear. Fructose has a critical role in fetal growth in early pregnancy, and might be a key role to developing preeclampsia. Here, we summarize the previous literatures regarding the physiological andpathological roles of fructose in pregnancy to propose studies to further investigate the pathogenesis of preeclampsia.

Takahiko Nakagawa
Ana Andres-Hernando
Richard J. Johnson
Reviews20 Dec 2022
Hypertension Research

Volume: 46, P: 646-653
A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury

Junko Okano
Yuki Nakae
Hideto Kojima
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-14
GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS

Natsuko Ohashi
Tomoya Terashima
Hideto Kojima
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-17

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Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus

Tamoxifen triggers a transcriptional switch from proliferation to differentiation in the circumvallate taste epithelium in mice

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities

Complete remission of diabetes with a transient HDAC inhibitor and insulin in streptozotocin mice

Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion

Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects

Fructose might be a clue to the origin of preeclampsia insights from nature and evolution

A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury

GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS

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