Nature Search

Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling

Interferon Regulatory Factor 5 levels have been shown to increase in adipose tissue macrophages in diet-induced obesity. Here authors show that IRF5 transcriptionally represses the Growth Hormone Inducible Transmembrane Protein gene encoding a mitochondrial protein important for oxidative respiration in macrophages, thus driving the detrimental metabolic changes observed in obesity.

L. Orliaguet
T. Ejlalmanesh
F. Alzaid
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-17
TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Tuberous sclerosis complex (TSC) is a multiorgan disease that can lead to hyperactive mTORC1 due to deficient TSC1 or TSC2 protein function. Here, the authors find that despite high mTORC1 activity, TFEB localizes to the nucleus and drives lysosomal gene expression via a non-canonical Rag-dependent mechanism.

Nicola Alesi
Elie W. Akl
Elizabeth P. Henske
ResearchOpen Access12 Jul 2021
Nature Communications

Volume: 12, P: 1-12
Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)

Heng-Jia Liu
Hilaire C. Lam
Elizabeth P. Henske
Research16 Aug 2019
Oncogene

Volume: 38, P: 7367-7383
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Autophagy is a physiological process that involves the engulfment and degradation of organelles. Choi and colleagues demonstrate that autophagy is important for the removal of damaged mitochondria and thus the control of inflammation.

Kiichi Nakahira
Jeffrey Adam Haspel
Augustine M K Choi
Research12 Dec 2010
Nature Immunology

Volume: 12, P: 222-230
Sea lice exposure to non-lethal levels of emamectin benzoate after treatments: a potential risk factor for drug resistance

Chun Ting Lam
Sarah M. Rosanowski
Sophie St-Hilaire
ResearchOpen Access22 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Renal disease in tuberous sclerosis complex: pathogenesis and therapy

Here, Lam and colleagues review advances in understanding the pathogenesis of tuberous sclerosis complex (TSC). Although rapalogues are effective cytostatic treatments for TSC, the unique metabolic vulnerabilities of cells lacking hamartin and/or tuberin might represent opportunities for developing cytocidal treatments.

Hilaire C. Lam
Brian J. Siroky
Elizabeth P. Henske
Reviews19 Sept 2018
Nature Reviews Nephrology

Volume: 14, P: 704-716
Subsidized veterinary extension services may reduce antimicrobial resistance in aquaculture

Sophie St-Hilaire
Stephen Chi Ho Chan
Olivia Sinn Kay Chan
ResearchOpen Access21 Jun 2023
Scientific Reports

Volume: 13, P: 1-8
Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Harilaos Filippakis
Amine Belaid
Elizabeth P. Henske
ResearchOpen Access21 Sept 2018
Scientific Reports

Volume: 8, P: 1-10

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