Neuroendocrine prostate cancers (NEPCs) are androgen independent and aggressive and have characteristics of epithelial–mesenchymal plasticity and stem-like cell properties. This Review describes the link between lineage plasticity and an emergent NEPC phenotype and how this knowledge can aid in the development of novel therapeutics.
- Alastair H. Davies
- Himisha Beltran
- Amina Zoubeidi
