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Showing 1–3 of 3 results
Advanced filters: Author: Hinrich Boeger Clear advanced filters

  • Using purified chromatin rings, what defines a promoter is now explored. Exposure of purified templates to the RSC ATP-dependent remodeling complex leads to Translocation of promoter rather than open reading frame nucleosomes. Together with analysis of the effect of histone deacetylase on this process, this argues that nucleosomes define promoter-specificity.

    • Yahli Lorch
    • Joachim Griesenbeck
    • Roger D Kornberg
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 881-885

  • Here the authors show that the regulatory mechanism for transcription of the yeast PHO5 gene operates away from equilibrium, contrary to common assumption about transcriptional regulatory processes. This occurs through the activation domain of the Pho4 activator, which mediates coupling to reservoirs of free energy.

    • Robert Shelansky
    • Sara Abrahamsson
    • Hinrich Boeger
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • The MuvB protein complex regulates genes that are differentially expressed through the cell cycle, yet its precise molecular function has remained unclear. Here the authors reveal MuvB associates with the nucleosome adjacent to the transcription start site of cell-cycle genes and that the tight positioning of this nucleosome correlates with MuvB-dependent gene repression.

    • Anushweta Asthana
    • Parameshwaran Ramanan
    • Seth M. Rubin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15