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Showing 1–4 of 4 results
Advanced filters: Author: Hinze Ho Clear advanced filters

  • Combining patch-clamp electrophysiology, molecular dynamics simulations, cryo-electron microscopy and imaging of neuronal synapses, the authors reveal how AMPA glutamate receptors are regulated by protons that are released from synaptic vesicles during signal transmission.

    • Josip Ivica
    • Nejc Kejzar
    • Ingo H. Greger
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1601-1613

  • AMPA glutamate receptors, mediate the majority of excitatory signaling in the brain. Here the authors show how the auxiliary subunit TARP-γ8 shapes gating kinetics, ion conductance and rectification properties of the heteromeric GluA1/2 AMPA receptor.

    • Beatriz Herguedas
    • Bianka K. Kohegyi
    • Ingo H. Greger
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Calcium-permeable GluA1 AMPA glutamate receptors are structurally and functionally distinct from the prototypical GluA2-containing AMPA receptors, impacting their role in signal transmission, synaptic plasticity and learning.

    • Danyang Zhang
    • Josip Ivica
    • Ingo H. Greger
    ResearchOpen Access
    Nature
    Volume: 621, P: 877-882

  • Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.

    • Jake F. Watson
    • Alexandra Pinggera
    • Ingo H. Greger
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15