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Showing 1–50 of 337 results

Advanced filters: Author: Hiroshi Okada Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Bone mineral loss damages renal tubules in mice

Enhanced bone resorption induced by sRANKL or microgravity releases phosphate into the circulation and causes crystal-induced tubular injury in mice, identifying bone-derived phosphate as a driver of kidney damage.

Hirosaka Hayashi
Yutaka Miura
Makoto Kuro-o
ResearchOpen Access22 Jan 2026
Communications Biology

P: 1-16
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Synthesis of Polydiacetylenes from Novel Monomers Having Two Diacetylene Units Linked by an Arylene Group

Hiroshi Matsuzawa
Shuji Okada
Hachiro Nakanishi
Research01 Feb 2001
Polymer Journal

Volume: 33, P: 182-189
Chemical Synthesis of Polysaccharides VI. Synthesis of (1→6) α-DL-Glucopyranan (DL-Dextran) by the Ring-Opening Polymerization Method

Masahiko Okada
Hiroshi Sumitomo
Yoshikazu Tada
Research01 Aug 1986
Polymer Journal

Volume: 18, P: 601-611
Cationic Ring-Opening Oligomerization of the Two Stereoisomers of 4-Bromo-6,8-dioxabicyclo[3.2.1]octan-7-one

Masahiko Okada
Hiroshi Sumitomo
Miharu Atsumi
Research01 Jan 1988
Polymer Journal

Volume: 20, P: 55-63
Chemical Synthesis of Polysaccharides. VIII. Synthesis and Enzymatic Hydrolysis of (1→6)-α-Linked Heteropolysaccharides Consisting of D-Glucose and 2,3,4-Trideoxy-DL-glycero-hexopyranose Units

Masahiko Okada
Hiroshi Sumitomo
Takahito Hirasawa
Research01 May 1987
Polymer Journal

Volume: 19, P: 581-591
Polymerization of Bicyclic Acetals. IX. Cationic Polymerization of 4-Bromo-6,8-dioxabicyclo[3.2.1]octane

Masahiko Okada
Hiroshi Sumitomo
Akira Sumi
Research01 Jan 1982
Polymer Journal

Volume: 14, P: 59-68
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Author Correction: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Yuki Ishikawa
Nao Tanaka
Chikashi Terao
Amendments and CorrectionsOpen Access19 Jan 2026
Nature Communications

Volume: 17, P: 1
Regioselectively Modified Stereoregular Polysaccharides X. Equilibrium Polymerization of 1,6-Anhydro-2-O-benzyl-3,4-dideoxy-β-D-threo-hexopyranose

Haruo Ichikawa
Kazukiyo Kobayashi
Hiroshi Sumitomo
Research01 Jul 1987
Polymer Journal

Volume: 19, P: 873-880
Chemical Synthesis of Polysaccharides III. A Synthetic Polysaccharide Having One Hydroxyl Group in Its Repeating Unit, 3,4-Dideoxy-(1→6)-α-DL-threo-hexopyranan

Masahiko Okada
Hiroshi Sumitomo
Ken Ogasawara
Research01 Nov 1983
Polymer Journal

Volume: 15, P: 821-826
Cationic Copolymerization of 1,3-Dioxolane with Tetrahydrofuran Initiated with Methyl Fluorosulfate

Yasuaki Yokoyama
Masahiko Okada
Hiroshi Sumitomo
Research01 Aug 1979
Polymer Journal

Volume: 11, P: 629-639
Polymerization of Bicyclic Acetals XVI. Substituent Effect of an Equatorially Oriented Benzyloxy Group in Position 3 on the Stereochemical Course of the Cationic Ring-Opening Polymerization of 6,8-Dioxabicyclo[3.2.1]octane Derivatives

Takahito Hirasawa
Masahiko Okada
Hiroshi Sumitomo
Research01 Jul 1988
Polymer Journal

Volume: 20, P: 587-596
Polymerization of Bicyclic Acetals XII. Synthesis and Polymerization of 4(a)-Benzyloxy-3(e)-cyano-6,8-dioxabicyclo[3.2.1]octane

Akira Sumi
Masahiko Okada
Hiroshi Sumitomo
Research01 Nov 1984
Polymer Journal

Volume: 16, P: 815-823
Chemical Synthesis of Polysaccharides I. Synthetic Polysaccharide Having One Hydroxyl Group in Its Repeating Unit, 3,4-Dideoxy-(1→6)-α-DL-erythro-hexopyranan

Masahiko Okada
Hiroshi Sumitomo
Ken Ogasawara
Research01 Oct 1982
Polymer Journal

Volume: 14, P: 815-821
Kinetic Studies on the Cationic Polymerization of 1,3-Dioxolane Initiated with Methyl Fluorosulfonate

Yasuaki Yokoyama
Masahiko Okada
Hiroshi Sumitomo
Research01 May 1979
Polymer Journal

Volume: 11, P: 365-370
Polymerization of Bicyclic Acetals. III. Cationic Copolymerization of 6,8-Dioxabicyclo[3.2.1]octane with Styrene

Masahiko Okada
Hiroshi Sumitomo
Yasuo Hibino
Research01 Jul 1975
Polymer Journal

Volume: 7, P: 511-518
Occurrence of Polynucleotide Phosphorylase in Atypical Epithelioma of Rat

KUNIO YAGI
TAKAYUKI OZAWA
HIROSHI KONOGI
Research19 Dec 1959
Nature

Volume: 184, P: 1939
Electrophysiological responses of Didinium nasutum to Paramecium capture and mechanical stimulation

Ritsuo Hara
Hiroshi Asai
Research28 Feb 1980
Nature

Volume: 283, P: 869-870
A layered ionic crystal of polar Li@C₆₀ superatoms

Metal-containing fullerene cages are widely known, but hard to characterize because of their reactivity towards empty cages. Now the molecular and crystal structures of lithium-containing C₆₀ molecules have been determined.

Shinobu Aoyagi
Eiji Nishibori
Hiromi Tobita
Research20 Jun 2010
Nature Chemistry

Volume: 2, P: 678-683
Plasma amino acid profile is altered by visceral fat accumulation and is a predictor of visceral obesity in humans

Takayuki Tanaka
Yuko Ishizaka
Minoru Yamakado
ResearchOpen Access19 Jan 2011
Nature Precedings

P: 1
Crystal Structures of the Cyclic Oligoesters from 6,8-Dioxabicyclo[3.2.1]octan-7-one. II. The Optically Inactive Cyclic Tetramer

Mikio Imaeda
Isao Tanaka
Hiroshi Sumitomo
Research01 Mar 1982
Polymer Journal

Volume: 14, P: 197-203
Regioselectively Modified Stereoregular Polysaccharides IX. A Synthetic Polysaccharide Having One Hydroxyl Group in Its Repeating Unit, 2,4-Dideoxy-(1→6)α-D-threo-hexopyranan

Kazukiyo Kobayashi
Hiroshi Sumitomo
Hiroaki Sugiura
Research01 Dec 1986
Polymer Journal

Volume: 18, P: 927-934
Expression and Tissue Localization of Membrane-Types 1, 2, and 3 Matrix Metalloproteinases in Rheumatoid Synovium

Hajime Yamanaka
Ken-ichi Makino
Yasunori Okada
Research01 May 2000
Laboratory Investigation

Volume: 80, P: 677-687
Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA

Shigeyuki Yokoyama
Tatsuo Miyazawa
Susumu Nishimura
Research01 Nov 1979
Nature

Volume: 282, P: 107-109
Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto
Research10 Sept 2025
Nature

Volume: 646, P: 62-67
A biodegradable polymer as a cytokine delivery system for inducing bone formation

Naoto Saito
Takao Okada
Kunio Takaoka
Research01 Apr 2001
Nature Biotechnology

Volume: 19, P: 332-335
CO₂-triggered reversible transformation of soft elastomers into rigid and highly fluorescent plastics

Carbon dioxide responsive polymers are promising for smart technologies, though it is challenging to effectively regulate these properties reliably. Here the authors report an elastomer composed of polyethyleneimine and polydimethylsiloxane which can reversibly its Young’s modulus responding to carbon dioxide.

Yohei Miwa
Kazuma Okada
Shoichi Kutsumizu
ResearchOpen Access11 Nov 2025
Nature Communications

Volume: 16, P: 1-9
Regioselectively Modified Stereoregular Polysaccharides XIII. Polymerization of 3-Deoxygenated 1,6-Anhydroglucopyranose Derivative

Kazukiyo Kobayashi
Hiroshi Sumitomo
Hiroshi Shiozawa
Research01 Feb 1989
Polymer Journal

Volume: 21, P: 137-146
Synthesis and Biodegradation of Polyesters Based on O-Methylene Tartaric Acid

Hiroshi Kimura
Terasu Yoshinari
Makoto Takeishi
Research01 Apr 1999
Polymer Journal

Volume: 31, P: 388-392
A New Tobacco Mosaic Virus Vector and its Use for the Systemic Production of Angiotensin-I-Converting Enzyme Inhibitor in Transgenic Tobacco and Tomato

Hiroshi Hamamoto
Yoshinori Sugiyama
Yoshimi Okada
Research01 Aug 1993
Bio/Technology

Volume: 11, P: 930-932
Study on Radical Chemistry of Monoperoxycarbonates by α-Methylstyrene Dimer Trapping Technique

Yasumasa Watanabe
Hideyo Ishigaki
Shuji Suyama
Research01 Mar 1998
Polymer Journal

Volume: 30, P: 192-196
Temperature Dependence of Initiation Reactions of Oxygen-Centered Radicals

Yasumasa Watanabe
Hideyo Ishigaki
Shuji Suyama
Research01 Aug 1997
Polymer Journal

Volume: 29, P: 693-696
New Method for Determination of Free-Radical Production Efficiency of Organic Peroxides and Azo Compounds

Yasumasa Watanabe
Hideyo Ishigaki
Shuji Suyama
Research01 Sept 1997
Polymer Journal

Volume: 29, P: 733-736
AML1(−/−) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene

Hitoshi Okada
Toshio Watanabe
Masanobu Satake
Research10 Oct 1998
Oncogene

Volume: 17, P: 2287-2293
Polymerization of Bicyclic Acetals. II. Steric Course in the Cationic Polymerization of 6,8-Dioxabicyclo[3.2.1]octane

Masahiko Okada
Hiroshi Sumitomo
Yasuo Hibino
Research01 Jun 1974
Polymer Journal

Volume: 6, P: 256-263
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Toshio Hirano
Kiyoshi Yasukawa
Tadamitsu Kishimoto
Research06 Nov 1986
Nature

Volume: 324, P: 73-76
A matrix metalloproteinase expressed on the surface of invasive tumour cells

Hiroshi Sato
Takahisa Takino
Motoharu Seiki
Research07 Jul 1994
Nature

Volume: 370, P: 61-65
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.

Minako Imamura
Atsushi Takahashi
Takashi Kadowaki
ResearchOpen Access28 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

Epithelial cells in the colon mainly use microbial fermentation products as energy sources. Here Okada et al. find that lactate produced by commensal Lactobacillus murinusregulates colonic epithelial cell proliferation and show that mice are more susceptible to carcinogens when refed after a period of starvation.

Toshihiko Okada
Shinji Fukuda
Taeko Dohi
Research03 Apr 2013
Nature Communications

Volume: 4, P: 1-10
Estimation of “Selective” Intravenous Gamma Globulin Treatment Indicated by Harada Score

Mamoru Ayusawa
Hiroshi Kanamaru
Kensuke Harada
Research01 Jan 2003
Pediatric Research

Volume: 53, P: 181
New Method for Determination of Hydrogen Abstraction Ability of Organic Peroxides

Yasumasa Watanabe
Hideyo Ishigaki
Shuji Suyama
Research01 Nov 1997
Polymer Journal

Volume: 29, P: 940-943
Study on Initiation Mechanisms of Peresters Using α-Methylstyrene Dimer (MSD) Trapping Technique

Yasumasa Watanabe
Hideyo Ishigaki
Shuji Suyama
Research01 Jul 1997
Polymer Journal

Volume: 29, P: 603-606
Regioselectively Modified Stereoregular Polysaccharides XIV. Synthesis of a C-Methylated Linear Dextran 3-C-Methyl-3-O-methyl-(1→6)-α-D-glucopyranan

Kazukiyo Kobayashi
Hiroshi Sumitomo
Mizunori Takahashi
Research01 Jul 1989
Polymer Journal

Volume: 21, P: 559-565
Urine phospholipid profiling in patients with rheumatoid arthritis and nontuberculous mycobacterial pulmonary disease

Hiroshi Furukawa
Shomi Oka
Shigeto Tohma
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-7
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18

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