(1H-indol-3-yl)methyl electrophiles are potential precursors for the synthesis of indole derivatives, however, their preparation remains challenging and only a few syntheses have been reported so far. Here, the authors examine previously reported preparations, clarify inconsistencies within the literature, and develop a highly versatile nucleophilic substitution at the indole 3’-position using microflow technologies.
- Hisashi Masui
- Sena Kanda
- Shinichiro Fuse
