Autophagy degrades invading bacteria in the cytoplasm, however, Listeria monocytogenes can efficiently escape autophagy. The Listeria protein ActA recruits the actin-regulators Arp2/3 and Ena/VASP to disguise it from autophagic recognition. Tagging PolyQ-containing, aggregate-prone proteins or a Golgi-membrane protein with ActA also prevents their autophagy-mediated degradation.
- Yuko Yoshikawa
- Michinaga Ogawa
- Chihiro Sasakawa
