Kohno, Kobayashi, Yamamoto et al. use a recent mouse model where the affinity of the cardiac ryanodine receptor (RyR2) to Calmodulin has been enhanced through a point mutation. They show that this mutation inhibits hypertrophic signaling and improves survival after pressure-induced overload, providing insights into the mechanisms of cardiac hypertrophy
- Michiaki Kohno
- Shigeki Kobayashi
- Masafumi Yano
