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Showing 1–8 of 8 results
Advanced filters: Author: Ho-Chul Kim Clear advanced filters

  • Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3.

    • Myeong-Suk Bahn
    • Dong-Min Yu
    • Young-Gyu Ko
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • In response to brain injury, microglia extend processes to isolate the lesion. Here Choi et al. show that microglia expressing a pathogenic mutation in the Parkinson’s disease-associated LRRK2 gene show reduced motility and delayed lesion isolation in vitro and in vivodue to attenuated focal adhesion kinase activity.

    • Insup Choi
    • Beomsue Kim
    • Eun-Hye Joe
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Prokaryotic condensins usually comprise an SMC homodimer, kleisin ScpA and ScpB. Structural and functional analyses of Bacillus subtilis condesin reveal an asymmetric bridge in which the termini of ScpA bind to distinct regions in each of the two SMC monomers. The findings suggest that the basic architecture for the tripartite condensin ring evolved before the emergence of eukaryotes.

    • Frank Bürmann
    • Ho-Chul Shin
    • Stephan Gruber
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 371-379

  • During cell division, chromosome alignment is engendered by connection of microtubules to kinetochores, coordinated by Aurora B and PLK1. Here, the authors show that the RSF1-PLK1 axis creates an activating phosphorylation on T236 in the GT motif of Aurora B and this is indispensable for Aurora B activation.

    • Ho-Soo Lee
    • Sunwoo Min
    • Hyeseong Cho
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • In this study, the authors show that overexpression/accumulation of the parkin substrate AIMP2 induces an age-dependent degeneration of dopaminergic neurons and results in motor dysfunction. This effect is dependent on AIMP2-induced activation of PARP1, which, in turn, induces cell death via parthanatos.

    • Yunjong Lee
    • Senthilkumar S Karuppagounder
    • Ted M Dawson
    Research
    Nature Neuroscience
    Volume: 16, P: 1392-1400