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Showing 1–3 of 3 results
Advanced filters: Author: Hocine W. Mankouri Clear advanced filters

  • Analysis of DNA replication fork arrest is challenging due to lack of techniques that induce site-specific replication barriers in eukaryotic chromosomes. Here, Larsen et al. create a novel tool to trigger targeted replication fork pausing by engineering the bacterial Tus–Tersystem into the yeast genome.

    • Nicolai B. Larsen
    • Ehud Sass
    • Ian D. Hickson
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.

    • Sheroy Minocherhomji
    • Songmin Ying
    • Ian D. Hickson
    Research
    Nature
    Volume: 528, P: 286-290

  • Chromosomal fragile sites (CFSs) are prone to breakage and thus can cause genomic instability. Hickson and colleagues demonstrate that the MUS81 endonuclease localizes to CFSs and mediates their processing, revealing that CFS cleavage is an active process.

    • Songmin Ying
    • Sheroy Minocherhomji
    • Ian D. Hickson
    Research
    Nature Cell Biology
    Volume: 15, P: 1001-1007