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Showing 1–3 of 3 results
Advanced filters: Author: Hoimin Jung Clear advanced filters

  • Strategies for the asymmetric synthesis of β-lactams are highly sought after. Now, a NiH-catalysed enantioselective intramolecular hydroamidation of alkenes affording β-lactam scaffolds is described, whereby the C–N bond is formed with unusual regioselectivity at the more proximal position.

    • Xiang Lyu
    • Changhyeon Seo
    • Sukbok Chang
    Research
    Nature Catalysis
    Volume: 6, P: 784-795

  • There is currently a lack of effective synthetic strategies for combining lactams and pyridines within a single molecular structure. Now, diastereoselective pyridyl lactamization has been developed using a photoinduced [3+2] cycloaddition of triplet diradical N–N pyridinium ylides with pendant alkenes. This method provides a useful synthon for preparing pyridyl γ- and δ-lactam scaffolds with syn-configuration.

    • Wooseok Lee
    • Yejin Koo
    • Sungwoo Hong
    Research
    Nature Chemistry
    Volume: 15, P: 1091-1099

  • Although many natural products and drug molecules contain N–N linkages, the chemistry of N–N coupling is somewhat underdeveloped. Now, a nitrene-mediated intermolecular N–N coupling of dioxazolones and arylamines that relies on iridium or iron catalysis has been developed. These reactions offer a simple and efficient method for the synthesis of hydrazides from readily available precursors.

    • Hao Wang
    • Hoimin Jung
    • Gong Chen
    Research
    Nature Chemistry
    Volume: 13, P: 378-385