Metal-catalysed enantioselective fluorination of C(sp3)–H bonds is an attractive method for preparing chiral organofluorines, but the challenge of achieving both enantioselectivity and reductive elimination selectivity remains unsolved. Now, it has been demonstrated that a chiral amino amide transient directing group can serve as a ligand for a palladium catalyst that promotes both enantioselective C(sp3)–H insertion and C(sp3)–F-selective reductive elimination.
- Hojoon Park
- Pritha Verma
- Jin-Quan Yu
