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Showing 1–7 of 7 results
Advanced filters: Author: Holger Greschik Clear advanced filters

  • The amino-terminal tails of histone proteins are subject to a variety of post-translational modifications; addition or removal of these 'marks' facilitates gene activation or silencing. Here, a mechanism is defined that modulates the activity of the dual-specificity histone demethylase LSD1 during androgen-dependent transcription. Androgen-dependent signalling through protein kinase C beta I leads to phosphorylation of a histone amino acid, which prevents demethylation of an adjacent amino acid by LSD1.

    • Eric Metzger
    • Axel Imhof
    • Roland Schüle
    Research
    Nature
    Volume: 464, P: 792-796

  • Prostate cancer growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). Here the authors find that a histone methyltransferase KMT9 is localized in the mitochondria of prostate cancer cells to regulate PDC activity by methylating its subunit DLAT.

    • Yanhan Jia
    • Sheng Wang
    • Roland Schüle
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • KMT9, a new histone lysine methyltransferase targeting H4K12, is enriched at promoters of genes encoding molecules involved in the cell cycle and controls the growth of androgen receptor–dependent and castration- and enzalutamide-resistant prostate cancer cells and xenograft tumors.

    • Eric Metzger
    • Sheng Wang
    • Roland Schüle
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 361-371

  • Brown adipocytes are rich in mitochondria and influence whole-body energy balance. Here, Duteil et al. show that the lysine-specific demethylase 1 (LSD1) controls mitochondrial biogenesis and the formation of brown-like adipocytes, and that LSD1 overexpression in white fat reduces weight gain of mice on a high-fat diet.

    • Delphine Duteil
    • Eric Metzger
    • Roland Schüle
    Research
    Nature Communications
    Volume: 5, P: 1-14