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Showing 1–7 of 7 results

Advanced filters: Author: Holger H. H. Erb Clear advanced filters

Circadian rhythm as a therapeutic target

Disregulation of circadian rhythms, as a result of jet lag or other lifestyle factors, can increase the risks of certain diseases. This Review analyses the different pathways involved in the regulation of the circadian clock and strategies that target the circadian systems.

Wei Ruan
Xiaoyi Yuan
Holger K. Eltzschig
Reviews15 Feb 2021
Nature Reviews Drug Discovery

Volume: 20, P: 287-307
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis

Vladimir Grubišić
Vedrana Bali
Brian D. Gulbransen
ResearchOpen Access22 Jul 2022
Mucosal Immunology

Volume: 15, P: 964-976
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer

Alicia-Marie K. Beier
Celina Ebersbach
Holger H. H. Erb
ResearchOpen Access15 May 2024
Oncogene

Volume: 43, P: 2038-2050
DNA methylation profiling in the clinic: applications and challenges

Epigenetic alterations, notably in DNA hypermethylation, are emerging as consistent biomarkers for disease. Here, with a focus on cancer, the authors discuss the identification of these biomarkers and their use in disease diagnosis, prognosis and response to therapy.

Holger Heyn
Manel Esteller
Reviews04 Sept 2012
Nature Reviews Genetics

Volume: 13, P: 679-692
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Andrea Eigentler
Florian Handle
Martin Puhr
ResearchOpen Access29 Nov 2023
Oncogene

Volume: 43, P: 235-247
The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy

Robert I. Seed
Alberto J. Taurozzi
Anne T. Collins
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling

G Nappo
F Handle
H H H Erb
ResearchOpen Access29 May 2017
Oncogenesis

Volume: 6, P: e342