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Showing 1–13 of 13 results
Advanced filters: Author: Hong-Erh Liang Clear advanced filters

  • Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occurs during parasite infections.

    • Kouki K. Touhara
    • Jinhao Xu
    • David Julius
    ResearchOpen Access
    Nature
    P: 1-9

  • Locksley and colleagues describe a nutrient-sensing circuit in the small intestine. Upon feeding, TSLP production from fibroblasts is increased in a GLP-2-dependent manner, resulting in increased ILC2 activation and tuft cell hyperplasia, thus linking food intake with ILC2 activation.

    • Chang Liao
    • Elvira Mennillo
    • Richard M. Locksley
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 2218-2226

  • The contribution of basophils to allergic and helminth immunity remains unclear. Locksley and colleagues use reporter strains and two-photon microscopy to demonstrate that basophils do not mediate T helper type 2 priming in vivo.

    • Brandon M Sullivan
    • Hong-Erh Liang
    • Richard M Locksley
    Research
    Nature Immunology
    Volume: 12, P: 527-535

  • Locksley et al. show tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice. Skin ILC2s are preferentially activated by IL-18, and IL-18 contributes to inflammation in a mouse model of atopic dermatitis.

    • Roberto R. Ricardo-Gonzalez
    • Steven J. Van Dyken
    • Richard M. Locksley
    Research
    Nature Immunology
    Volume: 19, P: 1093-1099

  • High-affinity isotype-switched B cells arise in germinal centers. Locksley and colleagues show that follicular helper T cells are the main cytokine providers for GC B cells and thereby directly influence the ensuing antibody response.

    • R Lee Reinhardt
    • Hong-Erh Liang
    • Richard M Locksley
    Research
    Nature Immunology
    Volume: 10, P: 385-393

  • Type 2 responses can be elicited by ILC2s and TH2 cells. Locksley and colleagues show that the epithelium-derived cytokines IL-25, IL-33 and TSLP are required for full effector activation of poised ILC2 and primed TH2 cell populations.

    • Steven J Van Dyken
    • Jesse C Nussbaum
    • Richard M Locksley
    Research
    Nature Immunology
    Volume: 17, P: 1381-1387

  • Epithelial tuft cells are shown to be the source of intestinal interleukin (IL)-25 that is required for activation of type 2 innate lymphoid cells (ILC2s), ILC2-regulated tuft and goblet cell expansion, and control of parasite infection.

    • Jakob von Moltke
    • Ming Ji
    • Richard M. Locksley
    Research
    Nature
    Volume: 529, P: 221-225

  • The biopolymer chitin is one of the main components in the cell walls of fungi, the exoskeletons of insects and crustaceans and the bodies of some parasitic worms. This paper describes how chitin elicits an innate allergic response in mice, which is controlled by a host chitinase.

    • Tiffany A. Reese
    • Hong-Erh Liang
    • Richard M. Locksley
    Research
    Nature
    Volume: 447, P: 92-96

  • Eosinophil recruitment to the lung and intestine is regulated by type-2-innate-lymphoid-cell-derived IL-5 and IL-13; IL-5 is shown to be induced by the neuropeptide vasoactive intestinal peptide, which is known to coordinate pancreatic secretion with smooth muscle relaxation in response to feeding.

    • Jesse C. Nussbaum
    • Steven J. Van Dyken
    • Richard M. Locksley
    Research
    Nature
    Volume: 502, P: 245-248