Nature Search

Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

A cross-ancestry GWAS meta-analysis of β-amyloid deposition in East Asian and European populations identifies a novel SORL1 locus and highlights its differential expression in microglia associated with β-amyloid positivity.

Jun Pyo Kim
Sang-Hyuk Jung
Hong-Hee Won
ResearchOpen Access02 Apr 2025
Nature Communications

Volume: 16, P: 1-12
Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability

Here the authors reveal via whole genome sequencing of an East Asian AD cohort a common variant locus (APCDD1), rare noncoding variants in excitatory neurons, and short tandem repeat expansions, suggesting a cumulative effects model for Alzheimer’s risk.

Jun Pyo Kim
Minyoung Cho
Hong-Hee Won
ResearchOpen Access26 May 2025
Nature Communications

Volume: 16, P: 1-18
Large-scale cross-ancestry genome-wide meta-analysis of serum urate

This large-scale cross-ancestry genome-wide association study reveals the genetic architecture of serum urate across ancestries and identifies urate-associated diseases and potential targets of urate-lowering drugs.

Chamlee Cho
Beomsu Kim
Hong-Hee Won
ResearchOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color

Here, the authors perform a large GWAS for objectively quantified skin color in an East Asian population (N = 48,433), identifying potential causal genes, polygenic adaptations, and interaction between genetic variants and sun-exposure at polygenic level.

Beomsu Kim
Dan Say Kim
Hong-Hee Won
ResearchOpen Access07 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Shared genetic architectures of subjective well-being in East Asian and European ancestry populations

Won et al. compare genetic associations with subjective well-being in Korean and European populations, and show significant cross-population genetic correlations

Soyeon Kim
Kiwon Kim
Hong-Hee Won
Research19 May 2022
Nature Human Behaviour

Volume: 6, P: 1014-1026
Polygenic overlap between subjective well-being and psychiatric disorders and cross-ancestry validation

Jung et al. show the existence of polygenic overlap and associations between subjective well-being and psychiatric disorders.

Jin Young Jung
Yeeun Ahn
Hong-Hee Won
Research14 Apr 2025
Nature Human Behaviour

Volume: 9, P: 1272-1282
Shared genetic architectures of educational attainment in East Asian and European populations

The authors conducted a genome-wide association study of educational attainment in an East Asian ancestry cohort, and a cross-ancestry meta-analysis with earlier genome-wide association studies from European ancestry populations, providing new insights into correlations and transferability between ancestries.

Tzu-Ting Chen
Jaeyoung Kim
Hong-Hee Won
ResearchOpen Access05 Jan 2024
Nature Human Behaviour

Volume: 8, P: 562-575
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome

Large-scale multivariate analyses across populations of European ancestry identify risk loci for the metabolic syndrome, improving polygenic prediction models and highlighting associations with diverse traits beyond cardiometabolic diseases.

Sanghyeon Park
Soyeon Kim
Hong-Hee Won
ResearchOpen Access30 Sept 2024
Nature Genetics

Volume: 56, P: 2380-2391
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4

How brain glial cells form an immune memory can impact disease pathology. Here, the authors show astrocyte priming boosts Aβ clearance by microglia, a protective mechanism that is disrupted by the APOE4 genetic risk factor.

Se-In Lee
Jichang Yu
Jinsoo Seo
ResearchOpen Access14 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: Fine-mapping genomic loci refines bipolar disorder risk genes

Maria Koromina
Ashvin Ravi
Niamh Mullins
Amendments and CorrectionsOpen Access27 Oct 2025
Nature Neuroscience

Volume: 28, P: 2644-2645
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders

Kyeongmin Jung
Joohyun Yoon
Hong-Hee Won
ResearchOpen Access01 Jun 2023
Experimental & Molecular Medicine

Volume: 55, P: 1193-1202
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

Here, the authors show that genetic risk for hypertensive disorders of pregnancy increases cardiovascular risk, and present evidence suggesting that maintaining a healthy lifestyle and ideal metabolic status significantly reduces this risk.

Sang‑Hyuk Jung
Haemin Kim
Seung Mi Lee
ResearchOpen Access08 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes

In a genetic study, Kim, Ko et al. demonstrate that participating in leisure and social activities reduces the risk of various diseases, including cardiovascular disease.

Soyeon Kim
Hyunwoong Ko
Hong-Hee Won
Research02 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 15-25
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Clinical utility of polygenic scores for cardiometabolic disease in Arabs

Arabs account for 5% of the world population and have a high burden of cardiometabolic disease. Here, the authors optimize polygenic scores for 10 cardiometabolic traits in 5399 Arabs, achieving a performance on par with that among European-ancestry individuals.

Injeong Shim
Hiroyuki Kuwahara
Akl C. Fahed
ResearchOpen Access18 Oct 2023
Nature Communications

Volume: 14, P: 1-11
NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2

N-alpha-acetyltransferase 10 (NAA10) regulates cell growth and proliferation. Here the authors show that NAA10 also has a role in osteogenesis, by fine-tuning the activity of the osteogenic transcription factor Runx2.

Haejin Yoon
Hye-Lim Kim
Jong-Wan Park
Research07 Nov 2014
Nature Communications

Volume: 5, P: 1-14
Germline genetic scores associated with cancer gene expression and immune responses across multiple cancer types

Cha et al. investigate functional genetic scores associated with cancer-related gene expression and immune responses across 16 cancer types using UK Biobank data. Their findings suggest that significant functional genetic scores confer additional risk beyond conventional cancer PRS.

Soojin Cha
Injeong Shim
Hong-Hee Won
ResearchOpen Access01 Jul 2025
Communications Medicine

Volume: 5, P: 1-9
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

Hugh Watkins, Sekar Kathiresan, Ruth McPherson, Martin Farrall and colleagues report the results of a large genome-wide association meta-analysis of coronary artery disease based on 1000 Genomes imputation. They identify ten new risk loci and show that susceptibility to this disease is largely determined by common SNPs with small effect sizes.

Majid Nikpay
Anuj Goel
Martin Farrall
Research07 Sept 2015
Nature Genetics

Volume: 47, P: 1121-1130
CD137 induces adhesion and cytokine production in human monocytic THP-1 cells

Jung-Won Choi
Hyeon-Woo Lee
KyuBum Kwack
ResearchOpen Access01 Apr 2005
Experimental & Molecular Medicine

Volume: 37, P: 78-85
Inverted Quantum Dot Light Emitting Diodes using Polyethylenimine ethoxylated modified ZnO

Hong Hee Kim
Soohyung Park
Won Kook Choi
ResearchOpen Access10 Mar 2015
Scientific Reports

Volume: 5, P: 1-5
Analysis of protein-coding genetic variation in 60,706 humans

Exome sequencing data from 60,706 people of diverse geographic ancestry is presented, providing insight into genetic variation across populations, and illuminating the relationship between DNA variants and human disease.

Monkol Lek
Konrad J. Karczewski
Daniel G. MacArthur
ResearchOpen Access17 Aug 2016
Nature

Volume: 536, P: 285-291
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

Exome sequence analysis of nearly 10,000 people was carried out to identify alleles associated with early-onset myocardial infarction; mutations in low-density lipoprotein receptor (LDLR) or apolipoprotein A-V (APOA5) were associated with disease risk, identifying the key roles of low-density lipoprotein cholesterol and metabolism of triglyceride-rich lipoproteins.

Ron Do
Nathan O. Stitziel
Sekar Kathiresan
Research10 Dec 2014
Nature

Volume: 518, P: 102-106
HSF1–DBC1 axis drives prostate cancer progression by activating a metastatic transcriptional program

Sue Jin Moon
Hwa Jin Kim
Jeong Hoon Kim
ResearchOpen Access01 Oct 2025
Experimental & Molecular Medicine

Volume: 57, P: 2277-2291
Improving polygenic prediction in ancestrally diverse populations

PRS-CSx is a polygenic risk score construction method that improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations.

Yunfeng Ruan
Yen-Feng Lin
Tian Ge
Research05 May 2022
Nature Genetics

Volume: 54, P: 573-580
Association of glaucoma and lifestyle with incident cardiovascular disease: a longitudinal prospective study from UK Biobank

Jin A Choi
Su-Nam Lee
Jae-Seung Yun
ResearchOpen Access15 Feb 2023
Scientific Reports

Volume: 13, P: 1-7
Multimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction

Yeong Chan Lee
Jiho Cha
Hong-Hee Won
ResearchOpen Access02 Feb 2023
npj Digital Medicine

Volume: 6, P: 1-10
Author Correction: Improving polygenic prediction in ancestrally diverse populations

Yunfeng Ruan
Yen-Feng Lin
Tian Ge
Amendments and Corrections04 Jul 2022
Nature Genetics

Volume: 54, P: 1259
Contribution of SLC22A12 on hypouricemia and its clinical significance for screening purposes

Do Hyeon Cha
Heon Yung Gee
Sung Kweon Cho
ResearchOpen Access07 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis

Christina Loley
Maris Alver
Inke R. König
ResearchOpen Access12 Oct 2016
Scientific Reports

Volume: 6, P: 1-9
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

By sequencing the exomes of 10,503 individuals living in Pakistan, the authors identify rare predicted loss-of-function mutations that are estimated to knock out genes and correlate these mutations with a broad range of phenotypes, providing a framework for a human knockout project.

Danish Saleheen
Pradeep Natarajan
Sekar Kathiresan
Research13 Apr 2017
Nature

Volume: 544, P: 235-239
HMGCLL1 is a predictive biomarker for deep molecular response to imatinib therapy in chronic myeloid leukemia

Jong-Ho Park
Young Min Woo
Dennis (Dong Hwan) Kim
ResearchOpen Access16 Dec 2018
Leukemia

Volume: 33, P: 1439-1450
LINC02257 regulates malignant phenotypes of colorectal cancer via interacting with miR-1273g-3p and YB1

Mi-So Park
Seong Dong Jeong
Hyeon Ho Kim
ResearchOpen Access18 Dec 2024
Cell Death & Disease

Volume: 15, P: 1-16
Development and validation of a novel strong prognostic index for colon cancer through a robust combination of laboratory features for systemic inflammation: a prognostic immune nutritional index

Sang-Hyuk Jung
Jie Hao
Ji Won Park
Research05 Mar 2022
British Journal of Cancer

Volume: 126, P: 1539-1547
Impacts of gender and lifestyle on the association between depressive symptoms and cardiovascular disease risk in the UK Biobank

Su Nam Lee
Jae-Seung Yun
Dokyoon Kim
ResearchOpen Access04 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank

A phenome-wide genomic analysis on the UK Biobank cohort links >9,000 co-localized genes and >1,400 human phenotypes across a broad selection of human tissues, representing a useful resource for the investigation of relationships between gene expression, tissues, and human diseases.

Ghislain Rocheleau
Iain S. Forrest
Ron Do
ResearchOpen Access20 Aug 2022
Communications Biology

Volume: 5, P: 1-9
Interaction of genetic and environmental factors for body fat mass control: observational study for lifestyle modification and genotyping

Joon Ho Kang
Heewon Kim
Woong-Yang Park
ResearchOpen Access23 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
hnRNPK-regulated LINC00263 promotes malignant phenotypes through miR-147a/CAPN2

Woo Joo Lee
Chang Hoon Shin
Hyeon Ho Kim
ResearchOpen Access17 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-18
Comprehensive characterization of distinct genetic alterations in metastatic breast cancer across various metastatic sites

Soojin Cha
Esak Lee
Hong-Hee Won
ResearchOpen Access16 Jul 2021
npj Breast Cancer

Volume: 7, P: 1-11
Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals

Sung Kweon Cho
Beomsu Kim
Hong-Hee Won
ResearchOpen Access08 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
NF-κB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells

Won Jong Jin
Bongjun Kim
Zang Hee Lee
ResearchOpen Access17 Feb 2017
Experimental & Molecular Medicine

Volume: 49, P: e295
Ultrasensitive PbS quantum-dot-sensitized InGaZnO hybrid photoinverter for near-infrared detection and imaging with high photogain

We propose hybrid approach of two classes of PbS QD as NIR light absorber and IGZO as the photogenerated charges acceptor/transport semiconductor to create phototransistor for near infrared (NIR) detection/imaging. Such hybrid phototransistor shows photodetection capability between 700 and 1400 nm. We demonstrate a NIR (1300 nm) imager using photogating inverter pixel based on PbS/IGZO hybrid phototransistor.

Do Kyung Hwang
Young Tack Lee
Seongil Im
ResearchOpen Access08 Jan 2016
NPG Asia Materials

Volume: 8, P: e233

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