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Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.

Hong-Jen Lee
Chien-Feng Li
Chia-Hsin Chan
ResearchOpen Access14 Jun 2019
Nature Communications

Volume: 10, P: 1-16
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

The argine methyltransferase PRMT5 methylates EGFR. This modification increases EGFR trans-autophosphorylation and attenuates ERK pathway activation.

Jung-Mao Hsu
Chun-Te Chen
Mien-Chie Hung
Research23 Jan 2011
Nature Cell Biology

Volume: 13, P: 174-181
Tailoring grain sizes of the biodegradable iron-based alloys by pre-additive manufacturing microalloying

Chih-Chieh Huang
Tu-Ngoc Lam
E-Wen Huang
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-12
Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy

Jiabei He
Hong-Jen Lee
Chia-Hsin Chan
ResearchOpen Access28 Mar 2019
Cell Death & Disease

Volume: 10, P: 1-16
Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response

Hong-Jen Lee
Li Lan
Mien-Chie Hung
Research20 Jan 2015
Cell Research

Volume: 25, P: 225-236