Nature Search

A multimodal vision–language model for generalizable annotation-free pathology localization

An annotation-free vision–language model based on contrastive learning performs pathology localization and clinical diagnosis on a wide variety of medical image datasets.

Hao Yang
Hong-Yu Zhou
Shanshan Wang
Research06 Jan 2026
Nature Biomedical Engineering

P: 1-15
Mammo-AGE: deep learning estimation of breast age from mammograms

The potential of mammogram-based biological age predictors remains to be fully explored. Here this group introduces a deep learning model to estimate the biological age of the breast using healthy mammograms.

Xin Wang
Tao Tan
Ritse Mann
ResearchOpen Access08 Dec 2025
Nature Communications

Volume: 16, P: 1-21
Identification of chronic myocardial infarction with extracellular or intravascular contrast agents in magnetic resonance imaging

Jian Wang
Hong-yu Liu
Gang-hong Tian
Research01 Jan 2008
Acta Pharmacologica Sinica

Volume: 29, P: 65-73
A transformer-based representation-learning model with unified processing of multimodal input for clinical diagnostics

A transformer-based representation-learning model that processes multimodal input in a unified manner outperformed non-unified multimodal models in two clinical diagnostic tasks.

Hong-Yu Zhou
Yizhou Yu
Weimin Li
Research12 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 743-755
Self-improving generative foundation model for synthetic medical image generation and clinical applications

A new AI generative model leverages the use of synthetic images to effectively augment existing datasets, boosting performance across multiple medical applications

Jinzhuo Wang
Kai Wang
Jia Qu
Research11 Dec 2024
Nature Medicine

Volume: 31, P: 609-617
An explainable longitudinal multi-modal fusion model for predicting neoadjuvant therapy response in women with breast cancer

Deep learning for medical image analysis is a promising new avenue to predict treatment response, however the clinical application of these methods has been so far limited. Here, the authors propose a model to predict chemotherapy response in breast cancer in real world clinical settings.

Yuan Gao
Sofia Ventura-Diaz
Ritse Mann
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Antioxidants used by Deinococcus radiodurans and implications for antioxidant drug discovery

Hong-Yu Zhang
Xue-Juan Li
Ling-Ling Chen
Correspondence01 Jun 2009
Nature Reviews Microbiology

Volume: 7, P: 476
Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1.

Yu-Hsin Chiu
Christopher B. Medina
Douglas A. Bayliss
ResearchOpen Access23 Jul 2021
Nature Communications

Volume: 12, P: 1-14
The draft genome of sweet orange (Citrus sinensis)

Yijun Ruan and colleagues report the draft genome of the sweet orange, Citrus sinensis. Their data suggests sweet orange originated from a cross between pummelo and mandarin.

Qiang Xu
Ling-Ling Chen
Yijun Ruan
ResearchOpen Access25 Nov 2012
Nature Genetics

Volume: 45, P: 59-66
Bioaggregate of photo-fermentative bacteria for enhancing continuous hydrogen production in a sequencing batch photobioreactor

Guo-Jun Xie
Bing-Feng Liu
Nan-Qi Ren
ResearchOpen Access05 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Diversity, abundance and activity of ammonia-oxidizing microorganisms in fine particulate matter

Jing-Feng Gao
Xiao-Yan Fan
Li-Xin Sun
ResearchOpen Access12 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

Wen-Tian He
Wei Xue
Hong-Yu Hu
ResearchOpen Access01 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity

Shi-Kun Zhang
Jin-wen Song
Shou-Ping Ji
ResearchOpen Access08 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
A novel protein-DNA interaction involved with the CpG dinucleotide at −30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene

Jie ZHANG
Jian YU
Jing De ZHU
Research01 Aug 2004
Cell Research

Volume: 14, P: 283-294
PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates

Hong-Wei Yue
Jun-Ye Hong
Hong-Yu Hu
ResearchOpen Access09 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

Jun-Ye Hong
Dong-Dong Wang
Hong-Yu Hu
ResearchOpen Access16 May 2019
Scientific Reports

Volume: 9, P: 1-12
Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

Lei-Lei Jiang
Jian Zhao
Hong-Yu Hu
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-11

Search

A multimodal vision–language model for generalizable annotation-free pathology localization

Mammo-AGE: deep learning estimation of breast age from mammograms

Identification of chronic myocardial infarction with extracellular or intravascular contrast agents in magnetic resonance imaging

A transformer-based representation-learning model with unified processing of multimodal input for clinical diagnostics

Self-improving generative foundation model for synthetic medical image generation and clinical applications

An explainable longitudinal multi-modal fusion model for predicting neoadjuvant therapy response in women with breast cancer

Antioxidants used by Deinococcus radiodurans and implications for antioxidant drug discovery

Deacetylation as a receptor-regulated direct activation switch for pannexin channels

The draft genome of sweet orange (Citrus sinensis)

Bioaggregate of photo-fermentative bacteria for enhancing continuous hydrogen production in a sequencing batch photobioreactor

Diversity, abundance and activity of ammonia-oxidizing microorganisms in fine particulate matter

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity

A novel protein-DNA interaction involved with the CpG dinucleotide at −30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates

Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

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