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Advanced filters: Author: Hongha Vu Clear advanced filters

  • Topoisomerase II (TOP2) has been identified as one of the regulators for the transcriptional activation of immediate early genes IEGs. Here the authors report that ERK1 and ERK2 oppositely regulate transcription and ERK2 regulates TOP2B-DNA interaction and catalysis to favor IEG transcription.

    • Heeyoun Bunch
    • Deukyeong Kim
    • Shun-ichi Sekine
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16