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Although quantum fluctuations of the spins occur on a local scale, they can have a macroscopic impact on the properties of magnets. Here, the authors observe the macroscopic influence of magnetic quantum fluctuations on the dielectric properties of a multiferroic oxide.

The genetic link between placenta function and congenital heart defects has been established, though the cellular mechanisms underlying this connection is less clear. Here they show that PIBF1 regulates syncytiotrophoblast fusion and that loss of PIBF1 also negatively impacts heart development, providing a potential link between the development of these two organs.

The fabrication of organic photovoltaic modules usually relies on patterning techniques which limit their efficiencies. Here, the authors propose a module structure that avoids the patterning steps, and use doctor-blade printing and slot-die coating to fabricate large-area modules reaching 7.5% efficiencies.

Using silicon nitride waveguides processed by plasma-enhanced chemical vapour deposition, full integration of ultrahigh-Q resonators with other photonic devices is now possible, representing a critical advance for future photonic circuits and systems.

ATE1 is an essential gene in mammals and is recognized as a master regulator of cells. Here, the authors describe structural insights into human ATE1, revealing mechanisms that regulate arginylation activity in cells.

Chimeric antigen receptor (CAR)-T cell is a promising therapy for hematological malignancy, but further optimization is still desirable. Here the authors show that incorporating CD99, a membrane protein expressed on activated T cells, transmembrane and juxtamembrane domains into CAR design helps improve CAR-T efficacy in vitro and in vivo in mice.

Valley depolarization processes in 2D transition metal dichalcogenides have been linked to acoustic phonons, but optical verification is ambiguous, due to the nearly degenerate acoustic phonon frequencies at the zone-edge. Here, the authors determine the phonon momentum of the longitudinal acoustic (LA) phonons at the K point as responsible for the ultrafast valley depolarization in monolayer MoSe₂.

There is still need for representative models of intrahepatic cholangiocarcinoma (ICC) subtypes. Here, the authors develop organoids for two recently suggested ICC subtypes and identify distinct transcriptional profiles and potential therapeutic targets.

Hereditary deafness lacks effective biological treatments. Here, the authors develop a base editing therapy that corrects a common MPZL2 deafness gene mutation in a humanized mouse model and restores hearing, highlighting base editing as a potential treatment for hereditary deafness.

Although artificial skins can facilitate the healing of damaged skin, the restoration of tactile functions remain a challenge. Here, Kang et al. report an artificial skin with an implantable tactile sensor that can simultaneously replace the tactile function by nerve stimulation and promote skin regeneration.

A method for annealing metal-oxide semiconductor films with deep-ultraviolet light yields thin-film transistors with performance comparable to that of thermally annealed devices, and widens the range of substrates on which such devices can be fabricated.

To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism and cellular signaling.

Potassium oxide is used as a promotor in industrial ammonia synthesis, although metallic potassium is better in theory. Here, the authors demonstrate metallic potassium, an unstable metal that easily volatilizes at high temperature, can be used as a promotor for ammonia synthesis.

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

The role of chromatin rewiring of regulatory elements in multiple myeloma (MM) remains poorly understood. Here, the authors identify a super-enhancer driven gene, PPP1R15B whose perturbation confers vulnerability in MM cells and suggest it as a therapeutic target.

A pore size–segmented adsorption model was proposed to quantify methane (CH₄) uptake in porous carbons under varying pressures (1–35 bar). By defining a contribution factor (k_x), the model revealed that pores of 0.76–1.14 nm (d_ii) showed a linear correlation with CH₄ adsorption above 20 bar. These contribution values shifted to 35, 54, and 11% at 35 bar, suggesting that effective pore sizes increase with increasing pressure. Atomistic computations validated the energetics of the adsorption mechanism and supported the decoupled contribution framework, offering design insights for advanced gas storage and separation materials.

Jianjun Liu, Wei-Hua Jia, Adeline Seow, Dongxin Lin and colleagues report a genome-wide association study of B cell non-Hodgkin lymphoma in individuals of Chinese ancestry. They identify a new susceptibility locus on chromosome 3q27 in the intergenic region between BCL6 (B cell lymphoma protein 6) and LPP (lipoma preferred partner).

Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

Triple negative breast cancer (TNBC) patients often acquire resistant to chemotherapy. In this study, the authors identify the IRAK1 as the crucial driver of NF-κB-related cytokine secretion involved in TNBC metastasis and therapy resistance.

Ca2+ overload-induced mitochondrial dysfunction is considered a contributing factor alcohol-associated liver disease pathogenesis. Here the authors report that PDK4 promotes Ca2 + -channelling complex formation at the endoplasmic reticulum-mitochondria contact sites, which contributes to the pathogenesis of alcohol-associated liver disease in studies with male mouse and hepatocyte models.

The reversible control of magnetization by electrical fields is of relevance for information storage applications, but has been difficult to achieve in bulk materials. Here, the authors observe the reversal of magnetization up to about 100 K in Ba_0.5Sr_1.5Zn₂(Fe_0.92Al_0.08)₁₂O₂₂without any external magnetic field.

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

Genome-wide association studies of individuals from an isolated population (data from the Finnish biobank study FinnGen) and consequent meta-analyses facilitate the identification of previously unknown coding variant associations for both rare and common diseases.

Chip-based microresonator frequency combs are currently limited to the infrared spectral region. Here, the authors generate combs whose center frequency approaches the visible spectrum enabled by combining geometrical and mode-hybridization dispersion control in silica microresonators.

Mouse fibroblasts can be simultaneously directly reprogrammed into cardiomyocytes, endothelial cells and smooth muscle cells to form cardiac tissue structures that improve cardiac function on implantation into infarcted mouse hearts.

The development of a tandem catalyst, consisting of two distinct nanoscale-engineered layers, enables efficient multicarbon production with high CO₂ utilization in an acidic CO₂ electroreduction environment.

Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and contractility by modulating membrane fluidity and ER stress signaling.

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

Single-cell DNA methylation and transcriptomic glioma analyses link local DNA methylation disorder and cellular plasticity. Increases in disorder are associated with stress and disease progression, suggesting a role in shaping the therapeutic response.

The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62_ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62_ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.

Probabilistic computing has recently emerged as a promising energy-based computing system for solving non-deterministic polynomial-time-hard (NP-hard) problems. Here the authors develop a novel pbit unit, using NbO_x volatile memristor, in which a self-clocking oscillator harnesses noise-induced metal-insulator transition, enabling high-performance probabilistic computing.

Aligned arrays of single-crystalline monolayer TMD nanoribbons with high aspect ratios, as well as their lateral heterostructures, are realized, with the growth directed by the ledges on the β-Ga₂O₃ substrate. This approach provides an epitaxy platform for advanced electronics applications of TMD nanoribbons.