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Showing 1–9 of 9 results
Advanced filters: Author: Houra Merrikh Clear advanced filters

  • Head-on replication-transcription collisions occur within genes encoded on the lagging DNA strand. Here, the authors show that a large number of originally co-oriented (leading strand) genes have inverted to the head-on orientation, increasing both gene-specific mutation rates, and the overall evolvability of several bacterial pathogens.

    • Christopher N. Merrikh
    • Houra Merrikh
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Lag-time analysis was developed to measure in vivo replisome dynamics. Observed dynamics are both locus and cell-cycle dependent: Pauses of seconds are observed at wild-type ribosomal DNA loci, as well as temporal fork velocity oscillations.

    • Dean Huang
    • Anna E. Johnson
    • Paul A. Wiggins
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The authors develop an EM-based method to directly visualize R-loops. Applying this method to transcription-replication conflicts in human and bacterial cells, they show that DNA:RNA hybrids accumulate primarily behind replication forks, and are linked to fork slowing and fork reversal.

    • Henriette Stoy
    • Katharina Zwicky
    • Massimo Lopes
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 348-359

  • As the rates of replication and transcription are different, the machineries that carry out these processes are bound to clash on DNA. In contrast to results from head-on collisions, co-directional encounters have been shown to have mild effects in vitro, requiring no additional replication restart factors. It is now shown that in bacterial cells, both types of events require the activities of restart proteins to resume replication when a transcription complex is encountered.

    • Houra Merrikh
    • Cristina Machón
    • Panos Soultanas
    Research
    Nature
    Volume: 470, P: 554-557

  • Crystal structures of DltB, a bacterial membrane-bound O-acyltransferase, are reported both alone and in complex with the d-alanyl donor protein DltC.

    • Dan Ma
    • Zhizhi Wang
    • Wenqing Xu
    Research
    Nature
    Volume: 562, P: 286-290

  • Plasmids facilitate the evolution of antibiotic resistance but little is known about bacteria–plasmid evolution. Here, the authors show that when bacteria adapt to one plasmid, they become generally permissive to plasmid carriage.

    • Wesley Loftie-Eaton
    • Kelsie Bashford
    • Eva M. Top
    Research
    Nature Ecology & Evolution
    Volume: 1, P: 1354-1363

  • Encounters between the replication and transcription machineries occur frequently in bacterial cells and are detrimental to fitness. Here, Grossman, Wang and colleagues review the two different types of replication–transcription conflict and describe the mechanisms that bacteria use to prevent and resolve these conflicts.

    • Houra Merrikh
    • Yan Zhang
    • Jue D. Wang
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 449-458