Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Hozefa S. Bandukwala Clear advanced filters

  • The Nr4a family of transcription factors transactivate expression of the transcription factor Foxp3 and are essential for the generation of regulatory T cells. Mice deficient in all three members of the Nr4a family develop massive multiorgan inflammation.

    • Hozefa S Bandukwala
    • Anjana Rao
    News & Views
    Nature Immunology
    Volume: 14, P: 201-203

  • The transcriptional regulator PLZF controls many of the key effector functions of invariant natural killer T (iNKT) cells but it is not clear how PLZF itself is regulated. Here, Pereira et al. demonstrate that a methlytransferase Jarid2 regulates PLZF expression and thus controls iNKT cell maturation.

    • Renata M. Pereira
    • Gustavo J. Martinez
    • Anjana Rao
    Research
    Nature Communications
    Volume: 5, P: 1-14

  • The TET family of enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. Mutations in the gene encoding TET2 are frequently observed in myeloid malignancies. Here it is shown that these disease-associated mutations compromise TET2 catalytic activity; bone marrow samples from patients with TET2 mutations have low levels of 5hmC in genomic DNA, and TET2 is required for normal haematopoietic differentiation. Measurement of genomic 5hmC levels may prove valuable as a diagnostic tool in myeloid cancers.

    • Myunggon Ko
    • Yun Huang
    • Anjana Rao
    Research
    Nature
    Volume: 468, P: 839-843

  • Asthma is often characterized by Th2-mediated inflammatory responses, which are initiated by lung dendritic cells. Here, Williams et al.demonstrate that dendritic cell expression of transcription factor IRF4 drives Th2 differentiation through IL-33 and IL-10 activation.

    • Jesse W. Williams
    • Melissa Y. Tjota
    • Anne I. Sperling
    Research
    Nature Communications
    Volume: 4, P: 1-12

  • Stress can induce expression of norepinephrine, which can enhance neuroinflammation. Shaked, Hedrick and colleagues show that the transcriptional repressor Nr4a1 limits this stress-induced response by suppressing expression of tyrosine hydroxylase required for the synthesis of norepinephrine.

    • Iftach Shaked
    • Richard N Hanna
    • Catherine C Hedrick
    Research
    Nature Immunology
    Volume: 16, P: 1228-1234

  • The CXXC domains of TET2 (encoded by the distinct gene IDAX) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent reduction in TET catalytic activity; this regulation is dependent on DNA binding through the CXXC domain.

    • Myunggon Ko
    • Jungeun An
    • Anjana Rao
    Research
    Nature
    Volume: 497, P: 122-126

  • The widespread clinical translation and commercialization of cell-based therapies are hampered by challenges related to cell source, viability, potency, safety and scalability. Here, Veiseh and colleagues overview progress in the development of cell-based therapeutics and discuss how biological engineering approaches — including genome editing, synthetic biology and the use of biomaterials — are beginning to address key challenges in the field.

    • Caleb J. Bashor
    • Isaac B. Hilton
    • Omid Veiseh
    Reviews
    Nature Reviews Drug Discovery
    Volume: 21, P: 655-675