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Showing 1–4 of 4 results
Advanced filters: Author: Hsiung-Lin Tu Clear advanced filters

  • Analyses in supported lipid bilayers and in cells shed light on the roles of multiple SOS-membrane interactions in SOS's membrane recruitment and association, processive activation of Ras and signal attenuation.

    • Sune M Christensen
    • Hsiung-Lin Tu
    • Jay T Groves
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 838-846

  • Establishing protein gradients for asymmetric cell division is fundamental across all kingdoms of life. Here the authors construct asymmetric cell division in E. coli by localizing the expression of RNA polymerase using an orthogonal unipolar scaffold, and restricting diffusion of its products.

    • Da-Wei Lin
    • Yang Liu
    • Hsiao-Chun Huang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Single-cell proteomics is an emerging approach to characterize cell-to-cell differences. Here, the authors develop chips that enable complete proteomic sample processing down to the single-cell level and integrate them with DIA-MS into a streamlined single-cell proteomics workflow.

    • Sofani Tafesse Gebreyesus
    • Asad Ali Siyal
    • Hsiung-Lin Tu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Digital proximity ligation assay (dPLA) can measure proteins and mRNAs in single cells, but is not compatible with cell imaging and cannot quantify rare proteins due to a high dilution factor. Here the authors present an automated microfluidic device that combines live-cell imaging, chemical stimulation, and dPLA in a smaller reaction volume.

    • Jing Lin
    • Christian Jordi
    • Savaş Tay
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10