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Advanced filters: Author: Hu-Dan Pan Clear advanced filters

Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy

Immune checkpoint blockade therapy improved the survival rates of non-small cell lung cancer but only a proportion of patients benefit. Here authors follow the humoral and cellular immunological parameters of patients undergoing anti-PD1 therapy longitudinally and find that levels and functional properties of cytotoxic T cells, and especially CD8⁺CD101^hiTIM3⁺ cells determine the response.

Elaine Lai-Han Leung
Run-Ze Li
Liang Liu
ResearchOpen Access22 Aug 2023
Nature Communications

Volume: 14, P: 1-9
Taurine and proline promote lung tumour growth by co-regulating Azgp1/mTOR signalling pathway

Tu-Liang Liang
Ying Chen
Run-Ze Li
ResearchOpen Access28 Mar 2025
npj Precision Oncology

Volume: 9, P: 1-15
Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation

Run-Ze Li
Xing-Xing Fan
Liang Liu
ResearchOpen Access13 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-14
Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging

Nan-jie Zhou
Wei-Qian Bao
Run-Ze Li
ReviewsOpen Access01 Jul 2025
npj Aging

Volume: 11, P: 1-18

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