Feng et al. show that oxidized fish oil exacerbates alcoholic liver injury in mice by enhancing intestinal dysbiosis, barrier dysfunction, and hepatic inflammation that is mediated by gut-derived endotoxin. This study suggests that n-3 polyunsaturated fatty acids enriched in fish oil should be kept from oxidation to exert their health benefits.
- Ruibing Feng
- Ma Li-Juan
- Jian-Bo Wan
