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Showing 1–4 of 4 results

Advanced filters: Author: Huanyin Tang Clear advanced filters

Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation

Zhen and colleagues show that nuclear cGAS represses L1 retrotransposition to stabilize the genome by enhancing the interaction between ORF2p and the E3 ligase TRIM41 upon DNA damage, which leads to the ubiquitination and degradation of ORF2p.

Zhengyi Zhen
Yu Chen
Zhiyong Mao
ResearchOpen Access12 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Loss of the receptors ER, PR and HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer

Sun et al. identify the deubiquitinase USP15 as a regulator of PARP1 stability in triple-negative breast cancer and show that the hormone receptors ER, PR and HER2 inhibit USP15-mediated PARP1 stabilization, modulating base excision repair.

Xiaoxiang Sun
Huanyin Tang
Zhiyong Mao
Research03 Apr 2023
Nature Cancer

Volume: 4, P: 716-733
Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer

Here the authors find that farrerol directly binds to UCHL3 and activates its deubiquitinase activity, and that farrerol promotes development of SCNT embryos by enhancing HR repair and restoring epigenetic networks in a UCHL3-dependent manner.

Weina Zhang
Mingzhu Wang
Ying Jiang
ResearchOpen Access03 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy

Yu Chen
Zhen Li
Zhiyong Mao
ResearchOpen Access16 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-12