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Showing 1–8 of 8 results
Advanced filters: Author: Hugo D. Luján Clear advanced filters

  • Antigenic variation in protozoan parasites is considered a spontaneous process and antibodies to these variant antigens were cytotoxic. The clearance of the former antigen during antigenic switching is thought to occur by dilution of the original antigen. In this work, the authors provide in vitro and in vivo evidence, that low concentrations of antibodies against Variant-specific Surface Proteins (VSPs) of the intestinal parasite Giardia lamblia are not cytotoxic but induce a robust stimulation of the switching process and the release of the former antigen into extracellular microvesicles. This process is mediated by antibody-induced clustering of VSPs into Lo-phase membrane microdomains through the raftophilic capability of the highly conserved transmembrane domain of the VSPs.

    • Albano H. Tenaglia
    • Lucas A. Luján
    • Hugo D. Luján
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for oral administration.

    • Marianela C. Serradell
    • Lucía L. Rupil
    • Hugo D. Luján
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Analysis of 20 chemical and morphological plant traits at diverse sites across 6 continents shows that the transition from semi-arid to arid zones is associated with an unexpected 88% increase in trait diversity.

    • Nicolas Gross
    • Fernando T. Maestre
    • Yoann Le Bagousse-Pinguet
    Research
    Nature
    Volume: 632, P: 808-814

  • Protection afforded by inorganic minerals is assumed to make mineral-associated organic carbon less susceptible to loss under climate change than particulate organic carbon. However, a global study of soil organic carbon from drylands suggests that this is not the case.

    • Paloma Díaz-Martínez
    • Fernando T. Maestre
    • César Plaza
    Research
    Nature Climate Change
    Volume: 14, P: 976-982

  • Antigenic variation is a process by which pathogens switch surface antigen expression during infection to escape immune recognition. Giardia lamblia, a major cause of parasitic diarrhoea, is now shown to regulate antigenic variation by RNA interference.

    • César G. Prucca
    • Ileana Slavin
    • Hugo D. Luján
    Research
    Nature
    Volume: 456, P: 750-754