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Advanced filters: Author: Hugues Beauchemin Clear advanced filters

Genetic correction of sickle cell disease: Insights using transgenic mouse models

Marie-José Blouin
Hugues Beauchemin
Marie Trudel
Research01 Feb 2000
Nature Medicine

Volume: 6, P: 177-182
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.

Peiman Shooshtarizadeh
Anne Helness
Tarik Möröy
ResearchOpen Access20 Mar 2019
Nature Communications

Volume: 10, P: 1-16
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

Jennifer Fraszczak
Charles Vadnais
Tarik Möröy
ResearchOpen Access20 Jun 2018
Leukemia

Volume: 33, P: 110-121