The authors show that 13-cis-retinoic acid (13cRA) has an antiproliferative effect in MYCN-amplified neuroblastoma cells. Poly (I:C) synergized with 13cRA enhances anti-apoptotic effects through innate immune signaling and mitochondrial stress response in 13cRA-responsive neuroblastoma cells. In addition, a combination of 13cRA/poly (I:C) induces neural differentiation and inhibits vessel formation, leading to retarded tumor growth.
- Hui-Ching Chuang
- Hung-Yu Lin
- Jiin-Haur Chuang
