Nature Search

A reconfigurable photosensitive split-floating-gate memory for neuromorphic computing and nonlinear activation

All-in-one computing, which merges sensing, linear computing, and nonlinear activation, is a critical goal for next-generation AI hardware. Here, Zhang et al. introduce a high-speed, reconfigurable split-floating-gate memory, enabling multi-function integration within a unified platform and hardware native neuromorphic processing.

Zhi-Cheng Zhang
Yuan Li
Xu-Dong Chen
ResearchOpen Access14 Jan 2026
Nature Communications

P: 1-15
Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival

Chien-chung Chen
Hui-ling Chen
Being-sun Wung
Research13 Dec 2010
Acta Pharmacologica Sinica

Volume: 32, P: 62-69
A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia

Zhi-xin Chen
Hui-ling Zhang
Zheng-hong Qin
Research01 Apr 2006
Acta Pharmacologica Sinica

Volume: 27, P: 402-408
Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice

Obesity is a significant health risk, and current treatments are inadequate. This study reveals that AA005, an annonaceous acetogenin mimic, targets mitochondrial HADHA in adipose tissue to boost thermogenesis via the UCP1 pathway, providing a promising new strategy for obesity treatment.

Bing Han
Zhan-Ming Li
Li-Shun Wang
ResearchOpen Access22 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils

Jen-pei Lee
Yi-ching Li
Yu-hsiang Kuan
Research21 Jun 2010
Acta Pharmacologica Sinica

Volume: 31, P: 831-838
Survival benefit of sequential curative treatment for TACE suitable BCLC stage B HCC patients

Yuan-Jie Ding
Te-Sheng Chang
Sheng-Nan Lu
ResearchOpen Access29 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
The effect of BIM deletion polymorphism on intrinsic resistance and clinical outcome of cancer patient with kinase inhibitor therapy

Hou-Qun Ying
Jie Chen
Shu-Kui Wang
ResearchOpen Access15 Jun 2015
Scientific Reports

Volume: 5, P: 1-10
Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis

The fungus Cryptococcus neoformans can cause lethal meningoencephalitis in humans after initiating infection in the lung. Here, the authors describe the roles played by two C. neoformanscopper transporters in pathogen’s survival during lung and brain infection.

Tian-Shu Sun
Xiao Ju
Chen Ding
Research24 Nov 2014
Nature Communications

Volume: 5, P: 1-13
The antitumour effects of caloric restriction are mediated by the gut microbiome

The authors show that caloric restriction increases the intestinal abundance of Bifidobacterium bifidum, which in turn blunts tumour development in mice.

Yu-Qin Mao
Jia-Ting Huang
Li-Shun Wang
Research16 Jan 2023
Nature Metabolism

Volume: 5, P: 96-110
Bird flu in mammals

An engineered influenza virus based on a haemagglutinin protein from H5N1 avian influenza, with just four mutations, can be transmitted between ferrets, emphasizing the potential for a human pandemic to emerge from birds. See Letter p.420

Hui-Ling Yen
Joseph Sriyal Malik Peiris
News & Views02 May 2012
Nature

Volume: 486, P: 332-333
The computerized algorithm for renal assessment improves diagnostic accuracy of renal impairment in hospitalized patients

Chun-You Chen
Te-I. Chang
Hui-Ling Hsieh
ResearchOpen Access31 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Good prediction of treatment responses to neoadjuvant chemoradiotherapy for esophageal cancer based on preoperative inflammatory status and tumor glucose metabolism

Chuan Li
Jing-Wei Lin
Chien-Chih Chen
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.

Wei Zhou
Wen-hui Wu
Zhi-hao Zhang
ResearchOpen Access14 Oct 2022
Nature Communications

Volume: 13, P: 1-19
Antiemetic drug fosaprepitant exerts anti-tumor effects against NSCLC by targeting FAK to inhibit AKT and JNK/c-Jun pathways

Ying Wang
Yu-na Shao
Ze-yi Liu
Research10 Sept 2025
Acta Pharmacologica Sinica

Volume: 47, P: 404-418
Greater stress protein expression enhanced by combined prostaglandin A₁ and lithium in a rat model of focal ischemia

Xi-hui Xu
Yi-nan Hua
Zheng-hong Qin
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1097-1104
Dietary intake and nutritional status of patients with phenylketonuria in Taiwan

Hui-Ling Weng
Feng-Jung Yang
Yin-Hsiu Chien
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-6
Serological Response Predicts Normalization of Cerebrospinal Fluid Abnormalities at Six Months after Treatment in HIV-Negative Neurosyphilis Patients

Yao Xiao
Man-Li Tong
Jian-Jun Niu
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer

Hou-Qun Ying
Hui-Ling Sun
Shu-Kui Wang
ResearchOpen Access22 Jan 2015
Scientific Reports

Volume: 5, P: 1-5
Implantation of bFGF-treated islet progenitor cells ameliorates streptozotocin-induced diabetes in rats

Ge Li
Li-song Huang
Da-ru Lu
Research18 Oct 2010
Acta Pharmacologica Sinica

Volume: 31, P: 1454-1463
Positive Association between Urinary Concentration of Phthalate Metabolites and Oxidation of DNA and Lipid in Adolescents and Young Adults

Chien-Yu Lin
Pau-Chung Chen
Ta-Chen Su
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho

Wei Zhou
Min-min Chen
Zhi-hao Zhang
Research28 Mar 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2609-2623
Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction

Bi-cheng Liu
Hui-ling Xia
Yu-xiang Gong
Research01 Nov 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1810-1818
Impact of cooking oil fume exposure and fume extractor use on lung cancer risk in non-smoking Han Chinese women

Tzu-Yu Chen
Yao-Hwei Fang
Chao A. Hsiung
ResearchOpen Access21 Apr 2020
Scientific Reports

Volume: 10, P: 1-10
Point of Care eGFR and the Prediction of Outcomes in Pneumonia

Chi-won Suk
Shih-chang Hsu
Chung-te Liu
ResearchOpen Access11 Jun 2019
Scientific Reports

Volume: 9, P: 1-9
Metabolomics differences between silkworms (Bombyx mori) reared on fresh mulberry (Morus) leaves or artificial diets

Hui-Ling Dong
Sheng-Xiang Zhang
Shi-Qing Xu
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-16
The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma

Jia-hao Liu
Hui-ling Yang
Wei-yi Fang
Research16 Mar 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2687-2695
Acute Kidney Injury Predicts Mortality after Charcoal Burning Suicide

Yu-Chin Chen
Yi-Chia Tseng
Tzung-Hai Yen
ResearchOpen Access19 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Expression of Hepatocyte Transporters and Nuclear Receptors in Children With Early and Late-Stage Biliary Atresia

Huey-Ling Chen
Yu-Jung Liu
Mei-Hwei Chang
Research01 Jun 2008
Pediatric Research

Volume: 63, P: 667-673
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway

Han-wei Yang
Hui-ling Hong
Zhuo-ming Li
Research10 Jul 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1837-1846
Neonatal Dubin-Johnson Syndrome: Long-Term Follow-up and MRP2 Mutations Study

Jyh-Hong Lee
Huey-Ling Chen
Mei-Hwei Chang
Research01 Apr 2006
Pediatric Research

Volume: 59, P: 584-589
Renal protective effect of sacubitril/valsartan in patients with heart failure

Hui-Ling Hsieh
Chun-You Chen
Chung-Te Liu
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
Effects of cardiovascular medications on primary patency of hemodialysis arteriovenous fistula

Te-I. Chang
Cheng-Hsien Chen
Chung-Te Liu
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
ACE2-independent infection of T lymphocytes by SARS-CoV-2

Xu-Rui Shen
Rong Geng
Peng Zhou
ResearchOpen Access11 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-11
Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism

Shi-gang Qiao
Ying Sun
Hui-ling Zhang
Research12 Jul 2018
Acta Pharmacologica Sinica

Volume: 40, P: 35-45
Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells

Tai-Yu Lai
I-Ju Chen
Alice L. Yu
ResearchOpen Access06 Mar 2019
Cell Death Discovery

Volume: 5, P: 1-12
Hypertonic saline enhances the efficacy of aerosolized gentamicin against Pseudomonas aeruginosa

Hui-Ling Lin
Li-Chung Chiu
Chi-Shuo Chen
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation

Guan-Nan Li
Xue-Jiao Zhao
Qing-Lei Gao
ResearchOpen Access12 Sept 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-15
Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

Hui-Hui Yang
Hui-Ling Jiang
Cha-Xiang Guan
ResearchOpen Access28 Nov 2022
Experimental & Molecular Medicine

Volume: 54, P: 2077-2091
Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model

James T. Pearson
Misa Yoshimoto
Mikiyasu Shirai
ResearchOpen Access22 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis

Chia-Liang Lin
Tsung-Ho Ying
Yi-Hsien Hsieh
ResearchOpen Access06 May 2021
Cell Death & Disease

Volume: 12, P: 1-12
Effects of positive end-expiratory pressure on the predictability of fluid responsiveness in acute respiratory distress syndrome patients

Yen-Huey Chen
Ying-Ju Lai
Chung-Chi Huang
ResearchOpen Access13 May 2021
Scientific Reports

Volume: 11, P: 1-9
Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner

Chen-Lin Yu
Shun-Fa Yang
Hui-Ling Chiou
ResearchOpen Access28 May 2019
Cell Death & Disease

Volume: 10, P: 1-15
Annonaceous acetogenin mimic AA005 suppresses human colon cancer cell growth in vivo through downregulation of Mcl-1

Bing Han
Yu-xia Cao
Li-shun Wang
Research19 Jun 2018
Acta Pharmacologica Sinica

Volume: 40, P: 231-242
The role of doxycycline in the therapy of multidrug-resistant E. coli – an in vitro study

Chih-Cheng Lai
Chi-Chung Chen
Hung-Jen Tang
ResearchOpen Access18 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality

Yun-Zhu Guo
Li-Hua Sun
Da-Chuan Yin
ResearchOpen Access04 Dec 2014
Scientific Reports

Volume: 4, P: 1-8
Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy

Nanosized drug delivery systems (NDDS) targeting the programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) axis have remarkably potentiated cancer immunotherapy. In this review, the NDDS exploited for anti-PD-1/PD-L1 therapy, including dimerization of PD-L1 protein, downregulation of PD-L1 expression, and blockade of PD-1/PD-L1 interaction were summarized. The perspectives and challenges of NDDS-based anti-PD-1/PD-L1 therapy were discussed as well.

Jun-hao Li
Lu-jia Huang
Hai-jun Yu
Reviews28 Apr 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2749-2758

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