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Showing 1–4 of 4 results
Advanced filters: Author: Hui-Yun Jeong Clear advanced filters

  • Autophagy plays an important role in metabolic functions and increased autophagic activity may be beneficial for metabolic disorders. Here the authors screen a chemical library for enhancer of autophagic flux and identify small molecules that improve the metabolic profile by increasing lysosomial functions.

    • Hyejin Lim
    • Yu-Mi Lim
    • Myung-Shik Lee
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • This Perspective argues that early assessments of technology-market fit, as well as how the physics governing system performance evolves with scale, can de-risk technology development and accelerate deployment. The authors highlight tools and processes that can be used to assess both these factors at an early stage.

    • Thomas Moore
    • Andrew A. Wong
    • Sarah E. Baker
    Reviews
    Nature Chemical Engineering
    Volume: 1, P: 731-740

  • Kim, Hwang et al. use in vitro and in vivo models of autophagy disorder/metabolic dysfunction to show that in this context, the natural compound kaempferide is an autophagy enhancer and reveal that one of the underlying mechanisms governing this is mediated by the mitochondrial elongation factor TUFM. This insight may have therapeutic value in the treatment of metabolic disorders.

    • Dasol Kim
    • Hui-Yun Hwang
    • Ho Jeong Kwon
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17