Adipose tissue has an important role in metabolic homeostasis and undergoes age-related changes contributing to metabolic decline, via mechanisms that remain incompletely explored. Here the authors show that Crtc2 deficiency in adipocytes protects against age-related hyperactivation of the BCAA–mTORC1 axis and metabolic alterations.
- Hye-Sook Han
- Eunyong Ahn
- Seung-Hoi Koo