Nature Search

Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice

Technologies for monitoring electrophysiological effects of drugs in behaving animals have limitations. Here the authors report a wireless neural probe system with drug delivery capability for real-time monitoring of drug effects.

Yousang Yoon
Hyogeun Shin
Il-Joo Cho
ResearchOpen Access21 Sept 2022
Nature Communications

Volume: 13, P: 1-19
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Currently technologies for monitoring and controlling neural activities in 3D models are lacking. Here the authors report a 3D high-density multielectrode array, with optical stimulation and drug delivery, to investigate neural circuit dynamics in engineered 3D neural tissues.

Hyogeun Shin
Sohyeon Jeong
Il-Joo Cho
ResearchOpen Access21 Jan 2021
Nature Communications

Volume: 12, P: 1-18
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.

Eunee Lee
Seungjoon Lee
Eunjoon Kim
ResearchOpen Access25 Aug 2021
Nature Communications

Volume: 12, P: 1-20
Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions

Transcranial brain stimulation offers promising control of brain function. Here, the authors present a wireless transcranial optogenetic brain modulator for precise control of multiple brain regions, demonstrating its potential in studying complex behaviors and alleviating Parkinson’s symptoms.

Hyogeun Shin
Min-Ho Nam
Il-Joo Cho
ResearchOpen Access30 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo

Microelectromechanical neural probes can cause tissue damage and often cannot record from distant brain areas. Here the authors combine electrical recording, optical stimulation and microfluidic drug delivery in one multi-shank probe with thinner shanks to reduce damage and a flexible design to target long-range neural circuits.

Hyogeun Shin
Yoojin Son
Il-Joo Cho
ResearchOpen Access22 Aug 2019
Nature Communications

Volume: 10, P: 1-11
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis

A protocol for the production of human spinal-cord-like organoids that recapitulate the tube-forming morphogenesis of the early human spinal cord facilitates screening for antiepileptic drugs that can cause neural-tube defects.

Ju-Hyun Lee
Hyogeun Shin
Woong Sun
Research28 Mar 2022
Nature Biomedical Engineering

Volume: 6, P: 435-448
Miniaturized multicolor fluorescence imaging system integrated with a PDMS light-guide plate for biomedical investigation

Hyogeun Shin
Gun-Wook Yoon
Il-Joo Cho
ResearchOpen Access09 Feb 2023
npj Flexible Electronics

Volume: 7, P: 1-10
Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

Ju Young Lee
Sang Hoon Park
Ki Jun Yu
ResearchOpen Access27 Oct 2022
npj Flexible Electronics

Volume: 6, P: 1-14
Electrical impulse effects on degenerative human annulus fibrosus model to reduce disc pain using micro-electrical impulse-on-a-chip

JaeHee Shin
MinHo Hwang
Hyuk Choi
ResearchOpen Access09 Apr 2019
Scientific Reports

Volume: 9, P: 1-11
A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

Jungpyo Lee
Kyungmin Ko
Il-Joo Cho
ResearchOpen Access15 Jul 2019
Microsystems & Nanoengineering

Volume: 5, P: 1-11
In vivo optical modulation of neural signals using monolithically integrated two-dimensional neural probe arrays

Yoojin Son
Hyunjoo Jenny Lee
Il-Joo Cho
ResearchOpen Access23 Oct 2015
Scientific Reports

Volume: 5, P: 1-11

Search

Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions

Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo

Production of human spinal-cord organoids recapitulating neural-tube morphogenesis

Miniaturized multicolor fluorescence imaging system integrated with a PDMS light-guide plate for biomedical investigation

Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

Electrical impulse effects on degenerative human annulus fibrosus model to reduce disc pain using micro-electrical impulse-on-a-chip

A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

In vivo optical modulation of neural signals using monolithically integrated two-dimensional neural probe arrays

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