Accumulation of senescent retinal pigment epithelial (RPE) cells is associated with retinal aging and disease. Here, authors identify Bst2 as a membrane-localized marker upregulated in senescent RPE cells and develop an antibody-pluggable drug delivery platform targeting Bst2-expressing cells for targeted senotherapy.
- Jun Yong Oh
- Jae-Byoung Chae
- Ja-Hyoung Ryu