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Showing 1–3 of 3 results
Advanced filters: Author: Hyoungjoo Lee Clear advanced filters

  • Tau misfolds in Alzheimer’s disease, but how the link between tau filament structure and pathogenicity is unclear. This study shows that both filament core structure and phosphorylation in the fuzzy coat are required for full seeding capacity.

    • Alysa Kasen
    • Sofia Lövestam
    • Michael X. Henderson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Targeting CD8+ T cell exhaustion is a strategy to enhance immune checkpoint inhibition and to fight cancer. Here the authors show a NRF2-dependent role for the prostaglandin I2 receptor PTGIR in controlling T cell exhaustion.

    • Michael S. Dahabieh
    • Lisa M. DeCamp
    • Russell G. Jones
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1139-1151

  • Metabolite extraction with organic solvents is assumed to remove/denature proteins. Here, the authors uncover a vast landscape of >1,000 proteins in metabolite extracts. These proteins can retain catalytic activity and drive post-extraction metabolite changes, obscuring biological interpretation.

    • Rachel (Rae) J. House
    • Molly T. Soper-Hopper
    • Ryan D. Sheldon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17