Eunjung Lee, Peter Park, Dongwan Hong and colleagues report an analysis of cancer RNA sequencing data identifying approximately 900 somatic coding variants that cause disrupted splicing in cancer, leading to intron retention or exon skipping in many cases. Variants causing intron retention are enriched for loss-of-function mutations in tumor-suppressor genes.
- Hyunchul Jung
- Donghoon Lee
- Eunjung Lee
