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Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

Mycobacterium tuberculosis feeds on host fatty acids during infection, a process that requires a fructose bisphosphatase (FBPase) enzyme for gluconeogenesis. Here, Ganapathy et al.show that the bacterium has two different FBPases and that this enzymatic activity is required for full virulence.

Uday Ganapathy
Joeli Marrero
Sabine Ehrt
ResearchOpen Access10 Aug 2015
Nature Communications

Volume: 6, P: 1-12
Metabolic anticipation in Mycobacterium tuberculosis

When faced with hypoxic conditions, Mycobacterium tuberculosis adapts its metabolism to generate intermediates reserved for re-initiation of peptidoglycan biosynthesis that can be used as soon as it is re-exposed to normoxia.

Hyungjin Eoh
Zhe Wang
Kyu Y. Rhee
Research22 May 2017
Nature Microbiology

Volume: 2, P: 1-7
Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT

Yujin Kwon
Jiyoon Kim
Won Kyu Kim
ResearchOpen Access13 Sept 2023
Cell Death & Differentiation

Volume: 30, P: 2309-2321
YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior

Youngsic Jeon
Jeong Eun Yoo
Young Nyun Park
ResearchOpen Access18 Jun 2021
Experimental & Molecular Medicine

Volume: 53, P: 1055-1067
Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis

Jae Jin Lee
Juhyeon Lim
Hyungjin Eoh
ResearchOpen Access31 May 2018
Scientific Reports

Volume: 8, P: 1-13
Poor outcome of hepatocellular carcinoma with stemness marker under hypoxia: resistance to transarterial chemoembolization

Hyungjin Rhee
Ji Hae Nahm
Young Nyun Park
Research17 Jun 2016
Modern Pathology

Volume: 29, P: 1038-1049

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Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

Metabolic anticipation in Mycobacterium tuberculosis

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT

YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior

Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis

Poor outcome of hepatocellular carcinoma with stemness marker under hypoxia: resistance to transarterial chemoembolization

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Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis

Metabolic anticipation in Mycobacterium tuberculosis

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT

YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior

Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis

Poor outcome of hepatocellular carcinoma with stemness marker under hypoxia: resistance to transarterial chemoembolization

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