Wu et al. conduct a multi-year longitudinal study to examine the associations of within individual changes in leukocyte mitochondrial DNA copy number(mtDNACN) and serum hsCRP with mortality in older adults. They demonstrated super-additive interactions between a decrease in leukocyte mtDNACN and an increase in serum hs-CRP, indicating synergism.
- I-Chien Wu
- Chin-San Liu
- Pei-Fen Chen