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Showing 1–4 of 4 results
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  • Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelssonet al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insulin secretion by diabetic islets.

    • A. S. Axelsson
    • T. Mahdi
    • A. H. Rosengren
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The rare loss-of-function allele p.Arg138* in SLC30A8 (encoding ZnT8) mediates protection against type 2 diabetes (T2D) through promoting better insulin secretion and enhanced glucose responsiveness, suggesting ZnT8 as a target for T2D treatment.

    • Om Prakash Dwivedi
    • Mikko Lehtovirta
    • Leif Groop
    Research
    Nature Genetics
    Volume: 51, P: 1596-1606

  • Jones et al. examine the generalizability of the valence–dominance model of social judgements of faces in 41 countries across 11 world regions. They find evidence of both generalizability and variation, depending on the analytical method.

    • Benedict C. Jones
    • Lisa M. DeBruine
    • Nicholas A. Coles
    Research
    Nature Human Behaviour
    Volume: 5, P: 159-169