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Showing 1–4 of 4 results
Advanced filters: Author: Iain Martyn Clear advanced filters

  • Functionalisation of conjugated polymers is essential for performance in many applications, yet there are limited approaches to achieve this. Here the authors developed a method for the direct postpolymerisation modification of the aromatic backbone of conjugated polymers and used them to create multifunctional semiconducting nanoparticles.

    • Adam Creamer
    • Christopher S. Wood
    • Martin Heeney
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.

    • Olga Kondrashova
    • Monique Topp
    • Clare L. Scott
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • This protocol describes how to differentiate and image human embryonic stem cells on micropatterned colonies to create radially organized domains of the germ layers mimicking embryonic gastrulation in vitro.

    • Alessia Deglincerti
    • Fred Etoc
    • Aryeh Warmflash
    Protocols
    Nature Protocols
    Volume: 11, P: 2223-2232

  • Simunovic et al. use human embryonic stem cells to generate a three-dimensional model of a human pre-gastrulation epiblast and show that anterior–posterior symmetry breaking can be induced by BMP4 and WNT signalling.

    • Mijo Simunovic
    • Jakob J. Metzger
    • Eric D. Siggia
    Research
    Nature Cell Biology
    Volume: 21, P: 900-910