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Showing 1–2 of 2 results
Advanced filters: Author: Ian Bakanas Clear advanced filters

  • Promiscuous interactions underpin natural protein evolution, but ways to harness such promiscuity to design new functions remain underexplored. Now it is shown that mapping this promiscuity with geometric precision in a de novo protein can guide its redesign into a fluorophore binder and an efficient enzyme approaching the diffusion limit.

    • Yuda Chen
    • Sagar Bhattacharya
    • William F. DeGrado
    Research
    Nature Chemistry
    P: 1-11

  • Strategies that utilize the oxidation of unactivated C–H bonds are becoming increasingly popular in natural product total synthesis. This Review classifies and highlights the different strategic use-cases of oxidation reactions as they were applied in recent total syntheses.

    • Ian Bakanas
    • Robert F. Lusi
    • Richmond Sarpong
    Reviews
    Nature Reviews Chemistry
    Volume: 7, P: 783-799