Here, the authors show that CD8+ T cells egress from tumors via lymphatic vessels in a CXCL12/CXCR4-dependent manner. High-affinity antigen encounter inhibits CXCR4 and increases retention, while no encounter or weak affinity directs T cell exit to limit local tumor control.
- Maria M. Steele
- Abhinav Jaiswal
- Amanda W. Lund
