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Showing 1–6 of 6 results
Advanced filters: Author: Ian Liau Clear advanced filters

  • The authors reveal that the chromatin architectural proteins CTCF and RAD21 organize DNA around nuclear speckles to enhance gene induction. This structural organization, when disrupted as in Cornelia de Lange syndrome, impairs key gene functions, providing insight into potential disease mechanisms.

    • Ruofan Yu
    • Shelby Roseman
    • Shelley L. Berger
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1069-1080

  • Medulloblastoma is the most common malignant brain tumour in children; having assembled over 1,000 samples the authors report that somatic copy number aberrations are common in medulloblastoma, in particular a tandem duplication of SNCAIP, a gene associated with Parkinson’s disease, which is restricted to subgroup 4α, and translocations of PVT1, which are restricted to Group 3.

    • Paul A. Northcott
    • David J. H. Shih
    • Michael D. Taylor
    ResearchOpen Access
    Nature
    Volume: 488, P: 49-56

  • Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular convergence of MYCN and cAMP signaling pathways.

    • Patryk Skowron
    • Hamza Farooq
    • Michael D. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17