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Showing 1–4 of 4 results
Advanced filters: Author: Iannis Talianidis Clear advanced filters

  • Extensive cellular stress or DNA damage can alter nuclear morphology. Here, the authors show that cells lacking Setd8 or under metabolic stress internalize cytoplasmic material into the nucleus.

    • Ourania Galanopoulou
    • Evangelia C. Tachmatzidi
    • Iannis Talianidis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Brown adipocytes are rich in mitochondria and influence whole-body energy balance. Here, Duteil et al. show that the lysine-specific demethylase 1 (LSD1) controls mitochondrial biogenesis and the formation of brown-like adipocytes, and that LSD1 overexpression in white fat reduces weight gain of mice on a high-fat diet.

    • Delphine Duteil
    • Eric Metzger
    • Roland Schüle
    Research
    Nature Communications
    Volume: 5, P: 1-14

  • DNA repair occurs in the context of nuclear architecture. Assembly of the repair machinery on damaged chromatin and the ensuing signalling events require tight spatial and temporal coordination. Higher-order chromatin structure, chromatin dynamics and non-random global genome organization also influence genome maintenance.

    • Tom Misteli
    • Evi Soutoglou
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 243-254