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Nature Cell Biology (1)

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Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection

Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection.

Rachel E. Hodgson
Wan-Ping Huang
Tatyana A. Shelkovnikova
ResearchOpen Access18 Mar 2026
Nature Cell Biology

P: 1-17

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Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection

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